Substance P is a peptide mainly secreted by neurons and is involved in many biological
processes, including nociception and inflammation. Animal models have provided insights …

The tachykinins, exemplified by substance P, are one of the most intensively studied
neuropeptide families. They comprise a series of structurally related peptides that derive …

β-arrestins are versatile adapter proteins that form complexes with most G-protein-coupled
receptors (GPCRs) following agonist binding and phosphorylation of receptors by G-protein …

Homeostasis of multicellular organisms is critically dependent on the correct interpretation of
the plethora of signals which cells are exposed to during their lifespan. Various soluble …

The neurokinin 1 receptor (NK‐1R) is the main receptor for the tachykinin family of peptides.
Substance P (SP) is the major mammalian ligand and the one with the highest affinity. SP is …

Tissue injury may create a specific microenvironment for inducing the systemic participation
of stromal-like cells in the repair process. Here we show that substance P is an injury …

By binding to agonist-activated G protein-coupled receptors (GPCRs), β-arrestins mediate
homologous receptor desensitization and endocytosis via clathrin-coated pits. Recent data …

Communication between different cellular signaling systems has emerged as a common
principle that enables cells to integrate a multitude of signals from its environment …

Substance P (SP) is a tachykinin expressed by various cells in the nervous and immune
systems. SP is predominantly released by neurons and exerts its biological and …

Despite the great advances in target therapy, lung cancer remains the top cause of cancer-
related death worldwide. G protein-coupled receptor neurokinin-1 (NK1R) is shown to play …