[HTML][HTML] Oxidative stress and assisted reproduction: a comprehensive review of its pathophysiological role and strategies for optimizing embryo culture environment

A Agarwal, I Maldonado Rosas, C Anagnostopoulou… - Antioxidants, 2022 - mdpi.com
Oxidative stress (OS) due to an imbalance between reactive oxygen species (ROS) and
antioxidants has been established as an important factor that can negatively affect the …

[HTML][HTML] OXIDATIVE STRESS AND REPRODUCTIVE FUNCTION: Reactive oxygen species in the mammalian pre-implantation embryo

JC Deluao, Y Winstanley, RL Robker… - …, 2022 - rep.bioscientifica.com
In brief Reactive oxygen species are generated throughout the pre-implantation period and
are necessary for normal embryo formation. However, at pathological levels, they result in …

[HTML][HTML] Oxidative stress and mitochondrial dysfunction of granulosa cells in polycystic ovarian syndrome

Y Gao, Y Zou, G Wu, L Zheng - Frontiers in Medicine, 2023 - frontiersin.org
Polycystic ovarian syndrome (PCOS) is one of the leading causes of anovulatory infertility in
women, affecting 5%–15% of women of reproductive age worldwide. The clinical …

[HTML][HTML] Oxidative stress in assisted reproductive techniques, with a focus on an underestimated risk factor

P Mauchart, RA Vass, B Nagy, E Sulyok… - Current issues in …, 2023 - mdpi.com
Based on current findings, the presence of oxidative stress has a significant impact on the
quality of gametes and embryos when performing assisted reproductive techniques (ART) …

[HTML][HTML] Uterine fluid extracellular vesicles proteome is altered during the estrous cycle

J Piibor, A Waldmann, K Dissanayake… - Molecular & Cellular …, 2023 - ASBMB
Uterine environment is tightly and finely regulated via various signaling pathways mediated
through endocrine, exocrine, autocrine, juxtacrine, and paracrine mechanisms. In utero …

[HTML][HTML] Secretory proteomic responses of endometrial epithelial cells to trophoblast-derived extracellular vesicles

S Muhandiram, K Dissanayake, T Orro… - International Journal of …, 2023 - mdpi.com
Synchronized crosstalk between the embryo and endometrium during the periconception
period is integral to pregnancy establishment. Increasing evidence suggests that the …

[HTML][HTML] Effect of Micronutrients and L-Carnitine as Antioxidant on Sperm Parameters, Genome Integrity, and ICSI Outcomes: Randomized, Double-Blind, and Placebo …

M Lahimer, O Gherissi, N Ben Salem, H Ben Mustapha… - Antioxidants, 2023 - mdpi.com
The evaluation of sperm DNA integrity is recommended in the sixth edition of the 2021 World
Health Organization guidelines. Oxidative stress has been identified as a crucial factor …

Maternal metabolic health and fertility: we should not only care about but also for the oocyte!

J Leroy, B Meulders, K Moorkens… - Reproduction …, 2022 - CSIRO Publishing
Metabolic disorders due to obesity and unhealthy lifestyle directly alter the oocyte's
microenvironment and impact oocyte quality. Oxidative stress and mitochondrial dysfunction …

Antioxidant effects of Citrus sinensis peel essential oil in a bovine oocyte model

LVC de Aquino, MV de Oliveira Santos… - Livestock Science, 2023 - Elsevier
Essential oils are a rich source of bioactive antioxidants that can replace synthetic
compounds in cell culture systems. This study aimed to evaluate the antioxidant effects of …

[HTML][HTML] Embryos from Prepubertal Hyperglycemic Female Mice Respond Differentially to Oxygen Tension In Vitro

D Predheepan, SR Salian, S Uppangala, V Lakshmi R… - Cells, 2024 - mdpi.com
Reduced oxygen during embryo culture in human ART prevents embryo oxidative stress.
Oxidative stress is also the major mechanism by which maternal diabetes impairs embryonic …