[HTML][HTML] Challenges for immunotherapy for the treatment of platinum resistant ovarian cancer

O Le Saux, I Ray-Coquard, SI Labidi-Galy - Seminars in cancer biology, 2021 - Elsevier
Platinum resistant ovarian cancer, usually defined as progression occurring within 6 months
after completing platinum-based therapy, is a heterogeneous disease with poor prognosis …

Hippo signaling in the ovary: emerging roles in development, fertility, and disease

KL Clark, JW George, E Przygrodzka… - Endocrine …, 2022 - academic.oup.com
Emerging studies indicate that the Hippo pathway, a highly conserved pathway that
regulates organ size control, plays an important role in governing ovarian physiology …

Neutrophil extracellular traps: a new player in cancer metastasis and therapeutic target

D Yang, J Liu - Journal of Experimental & Clinical Cancer Research, 2021 - Springer
Abstract Neutrophil Extracellular Traps (NETs) are neutrophil-derived extracellular scaffolds,
which typically consist of fibrous decondensed chromatins decorated with histones and …

FOXM1: a multifunctional oncoprotein and emerging therapeutic target in ovarian cancer

C Liu, CJ Barger, AR Karpf - Cancers, 2021 - mdpi.com
Simple Summary Ovarian cancer is a lethal disease in women with a 10-year survival rate
of< 40% worldwide. A key molecular alteration in ovarian cancer is the aberrant …

Insights into the role of oxidative stress in ovarian cancer

DN Ding, LZ Xie, Y Shen, J Li, Y Guo… - Oxidative medicine …, 2021 - Wiley Online Library
Oxidative stress (OS) arises when the body is subjected to harmful endogenous or
exogenous factors that overwhelm the antioxidant system. There is increasing evidence that …

Synthesis of quercetin functionalized wurtzite type zinc oxide nanoparticles and their potential to regulate intrinsic apoptosis signaling pathway in human metastatic …

V Ramalingam, PM Sathya, T Srivalli, H Mohan - Life Sciences, 2022 - Elsevier
In the present study, the wurtzite (WZ) type of zinc oxide (ZnO) nanoparticles were
synthesized and functionalized with quercetin (ZnO@ Quercetin) for the treatment of ovarian …

Untargeted metabolomics analysis on kidney tissues from mice reveals potential hypoxia biomarkers

MI Sajid, FJ Nunez, F Amirrad, MR Roosan, T Vojtko… - Scientific Reports, 2023 - nature.com
Chronic hypoxia may have a huge impact on the cardiovascular and renal systems.
Advancements in microscopy, metabolomics, and bioinformatics provide opportunities to …

TRAIL-dependent apoptosis of peritoneal mesothelial cells by NK cells promotes ovarian cancer invasion

AM Steitz, C Schröder, I Knuth, CU Keber… - Iscience, 2023 - cell.com
A crucial requirement for metastasis formation in ovarian high-grade serous carcinoma
(HGSC) is the disruption of the protective peritoneal mesothelium. Using co-culture systems …

L1CAM is required for early dissemination of fallopian tube carcinoma precursors to the ovary

K Doberstein, R Spivak, HD Reavis, J Hooda… - Communications …, 2022 - nature.com
Most ovarian high-grade serous carcinomas (HGSC) arise from Serous Tubal Intraepithelial
Carcinoma (STIC) lesions in the distal end of the fallopian tube (FT). Formation of STIC …

Cellular models of development of ovarian high‐grade serous carcinoma: A review of cell of origin and mechanisms of carcinogenesis

J Mei, H Tian, HS Huang, CF Hsu, Y Liou… - Cell …, 2021 - Wiley Online Library
High‐grade serous carcinoma (HGSC) is the most common and malignant histological type
of epithelial ovarian cancer, the origin of which remains controversial. Currently, the …