Many pathological states characterized by muscle atrophy (eg, sepsis, cachexia, starvation,
metabolic acidosis and severe insulinopenia) are associated with an increase in circulating …

Myostatin, a member of the transforming growth factor-β superfamily, is a potent negative
regulator of skeletal muscle growth and is conserved in many species, from rodents to …

Up to 50% of cancer patients suffer from a progressive atrophy of adipose tissue and
skeletal muscle, called cachexia, resulting in weight loss, a reduced quality of life, and a …

Obesity and metabolic disorders such as type 2 diabetes mellitus are accompanied by
increased lipid deposition in adipose and non-adipose tissues including liver, pancreas …

Abstract Background and Aim: Cirrhosis is a state of accelerated starvation with impaired
protein synthesis. Increased rate of gluconeogenesis and alterations in skeletal muscle …

Myostatin is a powerful negative regulator of skeletal muscle mass in mammalian species. It
plays a key role in skeletal muscle homeostasis and has now been well described since its …

Imbalance of protein homeostasis, with excessive protein degradation compared with
protein synthesis, leads to the development of muscle atrophy resulting in a decrease in …

The presence of sufficient skeletal muscle mass is of paramount importance for body
function and the myostatin cascade is known to inhibit muscle growth in mammals. In …

Myostatin is a member of the transforming growth factor β superfamily of secreted growth
factors that negatively regulates skeletal muscle size. Mice null for the myostatin gene have …

Myostatin is an endogenous, negative regulator of muscle growth determining both muscle
fiber number and size. The myostatin pathway is conserved across diverse species ranging …