Pharmacogenetics and immunosuppressive drugs in solid organ transplantation
T Van Gelder, RH Van Schaik… - Nature Reviews …, 2014 - nature.com
The transplantation literature includes numerous papers that report associations between
polymorphisms in genes encoding metabolizing enzymes and drug transporters, and …
polymorphisms in genes encoding metabolizing enzymes and drug transporters, and …
Mycophenolate revisited
T van Gelder, DA Hesselink - Transplant International, 2015 - Wiley Online Library
The patent of mycophenolate mofetil (MMF) has expired, and for enteric‐coated
mycophenolate sodium (EC‐MPS), this will happen in 2017. In the twenty years these drugs …
mycophenolate sodium (EC‐MPS), this will happen in 2017. In the twenty years these drugs …
[HTML][HTML] A randomized controlled trial comparing the efficacy of Cyp3a5 genotype‐based with body‐weight‐based tacrolimus dosing after living donor kidney …
N Shuker, R Bouamar, RHN van Schaik… - American Journal of …, 2016 - Elsevier
Patients expressing the cytochrome P450 (CYP) 3A5 gene require a higher tacrolimus dose
to achieve therapeutic exposure compared with nonexpressers. This randomized‐controlled …
to achieve therapeutic exposure compared with nonexpressers. This randomized‐controlled …
The combination of CYP3A4* 22 and CYP3A5* 3 single-nucleotide polymorphisms determines tacrolimus dose requirement after kidney transplantation
N Lloberas, L Elens, I Llaudó, A Padullés… - Pharmacogenetics …, 2017 - journals.lww.com
Results EM had an 88% lower dose-adjusted C 0 compared with IM. PM had a 26% higher
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac …
dose-adjusted C 0 compared with IM. The percentage of patients with supratherapeutic Tac …
Which genetic determinants should be considered for tacrolimus dose optimization in kidney transplantation? A combined analysis of genes affecting the CYP3A locus
H Bruckmueller, AN Werk, L Renders… - Therapeutic drug …, 2015 - journals.lww.com
Background: Tacrolimus is established as immunosuppressant after kidney transplantation.
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Polymorphism of the cytochrome P450 3A5 (CYP3A5) gene contributes significantly to …
Dosing algorithms for initiation of immunosuppressive drugs in solid organ transplant recipients
LM Andrews, N Riva, BC de Winter… - Expert opinion on …, 2015 - Taylor & Francis
Introduction: Starting doses of tacrolimus and ciclosporin are typically chosen on a
calculated mg/kg bodyweight basis. After initiation of treatment, doses are adjusted with …
calculated mg/kg bodyweight basis. After initiation of treatment, doses are adjusted with …
Impact of single nucleotide polymorphisms (SNPs) on immunosuppressive therapy in lung transplantation
Lung transplant patients present important variability in immunosuppressant blood
concentrations during the first months after transplantation. Pharmacogenetics could explain …
concentrations during the first months after transplantation. Pharmacogenetics could explain …
Pharmacogenomic implications of population admixture: Brazil as a model case
G Suarez-Kurtz, DP Paula, CJ Struchiner - Pharmacogenomics, 2014 - Taylor & Francis
The heterogeneous Brazilian population, with European, African and Amerindian ancestral
roots is a model case for exploring the impact of population admixture on the frequency …
roots is a model case for exploring the impact of population admixture on the frequency …
Influence of IL‐18 and IL‐10 polymorphisms on tacrolimus elimination in Chinese Lung Transplant Patients
X Zhang, J Xu, J Fan, T Zhang, Y Li, B Xie… - Disease …, 2017 - Wiley Online Library
Aims. The influence of interleukin‐10 (IL‐10) and interleukin‐18 (IL‐18) polymorphisms on
tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The …
tacrolimus pharmacokinetics had been described in liver and kidney transplantation. The …
Genomewide association study reveals novel genetic loci associated with change in renal function in heart transplant recipients
R Asleh, D Snipelisky, M Hathcock… - Clinical …, 2018 - Wiley Online Library
Background Renal dysfunction occurs commonly after heart transplantation (HT x) with wide
inter‐individual variability but whether a genetic predisposition exists in these patients is …
inter‐individual variability but whether a genetic predisposition exists in these patients is …