Originally published in February 2004. This guideline is more than 5 years old and has not
yet been updated to ensure that it reflects current knowledge and practice. In accordance …

OBJECTIVE: The metabolic side effects of second-generation antipsychotics (SGA) are
serious and have not been compared head to head in a meta-analysis. We conducted a …

Objective: To formulate clinical practice guidelines for the pharmacological management of
obesity. Participants: An Endocrine Society-appointed Task Force of experts, a …

Introduction Antipsychotics (AP) induce weight gain. However, reviews and meta-analyses
generally are restricted to second generation antipsychotics (SGA) and do not stratify for …

The obesity epidemic is a global issue and shows no signs of abating, while the cause of
this epidemic remains unclear. Marketing practices of energy-dense foods and institutionally …

Patients with schizophrenia have increased mortality and morbidity compared with the
general population. These patients have a 20-year shorter lifespan than peers without …

OBJECTIVE: The aim of the study is to review the absolute and relative impacts of the major
causes for premature mortality among patients with schizophrenia. DATA SOURCES: We …

In this issue of Structure, Holmes et al.(2005) describe elements of an innate defense
mechanism that provides mammals a means to restrict bacterial growth. The host protein …

Clozapine, a dibenzodiazepine developed in 1961, is a multireceptorial atypical
antipsychotic approved for the treatment of resistant schizophrenia. Since its introduction, it …

OBJECTIVE: The authors review the mechanisms and establish the risk of torsade de
pointes and sudden death with antipsychotic drugs. METHOD: They present a review of …