Vaccination is generally considered to be the most effective method of preventing infectious
diseases. All vaccinations work by presenting a foreign antigen to the immune system in …

In this paper, current prediction methods and algorithms for both T‐and B cell epitopes are
reviewed, and a comprehensive summary of epitope prediction software and databases …

A wide range of regulatory processes in the cell are mediated by flexible peptides that fold
upon binding to globular proteins. Computational efforts to model these interactions are …

The development of immunological therapies that incorporate peptide antigens presented to
T cells by MHC proteins is a long sought-after goal, particularly for cancer, where mutated …

Molecular docking programs play an important role in drug development and many well‐
established methods exist. However, there are two situations for which the performance of …

T cell specificity emerges from a myriad of processes, ranging from the biological pathways
that control T cell signaling to the structural and physical mechanisms that influence how …

T cell immune responses are driven by the recognition of peptide antigens (T cell epitopes)
that are bound to major histocompatibility complex (MHC) molecules. T cell epitope …

T-cell specificity to differentiate between self and non-self relies on T-cell receptor (TCR)
recognition of peptides presented by the Major Histocompatibility Complex (MHC) …

Understanding the mechanisms involved in the activation of an immune response is
essential to many fields in human health, including vaccine development and personalized …

Genome sequences from many organisms, including humans, have been completed, and
high-throughput analyses have produced burgeoning volumes of 'omics' data …