Hepatic fibrosis is marked by excessive synthesis and deposition of connective tissue
proteins, especially interstitial collagens in the extracellular matrix of the liver. It is a result of …

During fibrosis,(myo) fibroblasts deposit large amounts of extracellular matrix proteins,
thereby replacing healthy functional tissue. In liver fibrosis, this leads to the loss of …

Platelets are tightly connected with the liver, as both their production and their clearance are
mediated by the liver. Platelets, in return, participate in a variety of liver diseases, ranging …

Non alcoholic steatohepatitis (NASH) is the inflammatory reaction of the liver to excessive
accumulation of lipids in the hepatocytes. NASH can progress to cirrhosis and …

Background: While platelet-rich plasma (PRP) has been widely studied for musculoskeletal
disorders, few studies to date have reported its use for adhesive capsulitis (AC). Fully …

Liver cirrhosis poses a global health challenge marked by significant prevalence and
mortality. Current therapeutic options are limited by high costs and immune-mediated …

Aims As a source of growth factors and with its cytoprotective properties, platelet-rich plasma
(PRP) received considerable attention in regenerative medicine. Thus, this study was …

Rheumatoid arthritis (RA) is a systemic chronic autoimmune disease manifested by joint
destruction and deformity, hence decreasing patient's life quality. The aim of the present …

Background: Post-traumatic joint contracture (PTJC) mainly manifests as excessive
inflammation leading to joint capsule fibrosis. Transforming growth factor (TGF)-β1, a key …

Hepatic fibrosis and cirrhosis are chronic diseases affecting liver and a major health
problem throughout the world. The hallmark of fibrosis and cirrhosis is inordinate synthesis …