Modelers of molecular signaling networks must cope with the combinatorial explosion of
protein states generated by posttranslational modifications and complex formation. Rule …

Deregulation of ErbB signaling plays a key role in the progression of multiple human
cancers. To help understand ErbB signaling quantitatively, in this work we combine …

Rule‐based modeling was developed to address the limitations of traditional approaches for
modeling chemical kinetics in cell signaling systems. These systems consist of multiple …

Grb2-associated binder 1 (GAB1) is a scaffold protein involved in numerous interactions that
propagate signaling by growth factor and cytokine receptors. Here we explore in silico and …

Given the combinatorial nature of cellular signalling pathways, where biological agents can
bind and modify each other in a large number of ways, concurrent or agent-based …

Epidermal growth factor receptors (ErbB1–4) are oncogenic receptor tyrosine kinases
(RTKs) that regulate diverse cellular processes. In this study, we combine measurement and …

The adaptive immune system is a dynamical, self-organized multiscale system that protects
vertebrates from both pathogens and internal irregularities, such as tumors. For these …

BRAF is prototypical of oncogenes that can be targeted therapeutically and the treatment of
BRAFV600E melanomas with RAF and MEK inhibitors results in rapid tumor regression …

The increasing availability of data related to genes, proteins and their modulation by small
molecules has provided a vast amount of biological information leading to the emergence of …

Vascular endothelial growth factor (VEGF) is a potent cytokine involved in the induction of
neovascularization. Secreted as a cysteine-linked dimer, it has two binding sites at opposite …