Ubiquitination of the epidermal growth factor receptor (EGFR) that occurs when Cbl and
Grb2 bind to three phosphotyrosine residues (pY1045, pY1068 and pY1086) on the receptor …

In both physiological and cell culture systems, EGF-stimulated ERK activity occurs in
discrete pulses within individual cells. Many feedback loops are present in the EGF receptor …

We present an algorithm, called BioLab, for verifying temporal properties of rule-based
models of cellular signalling networks. BioLab models are encoded in the BioNetGen …

Kinetic models are powerful tools, widely applied in many different fields of chemical
engineering and industrial chemistry. These models are typically expressed as large …

The dynamics of biological reaction networks are strongly constrained by thermodynamics.
An holistic understanding of their behavior and regulation requires mathematical models …

Background Rule-based modeling (RBM) is a powerful and increasingly popular approach
to modeling cell signaling networks. However, novel visual tools are needed in order to …

Cellular signalling pathways, where proteins can form complexes and undergo a large array
of post translational modifications are highly combinatorial systems sending and receiving …

Reconstructing cellular signaling networks and understanding how they work are major
endeavors in cell biology. The scale and complexity of these networks, however, render their …

Background: Receptors and scaffold proteins possess a number of distinct domains and
bind multiple partners. A common problem in modeling signaling systems arises from a …

Abstract Models that capture the chemical kinetics of cellular regulatory networks can be
specified in terms of rules for biomolecular interactions. A rule defines a generalized …