The rostral ventromedial medulla (RVM) is a bulbospinal nuclei in the descending pain
modulation system, and directly affects spinal nociceptive transmission through …

Spasticity is a complex and multidimensional disorder that impacts nearly 75% of individuals
with spinal cord injury (SCI) and currently lacks adequate treatment options. This …

The balance of ion concentrations inside and outside the cell is an essential homeostatic
mechanism in neurons and serves as the basis for a variety of physiological activities. In the …

In mammals, pain is regulated by the combination of an ascending stimulating and
descending inhibitory pain pathway. It remains an intriguing question whether such pain …

Spasticity is characterized by an enhanced size and reduced threshold for activation of
stretch reflexes and is associated with “positive signs” such as clonus and spasms, as well …

Significant bowel-related issues after spinal cord injury (SCI) that affect morbidity and quality
of life (QOL) include diminished bowel motility, loss of sphincter control, gastric ulcers …

Genomic screened homeobox 1 (Gsx1 or Gsh1) is a neurogenic transcription factor required
for the generation of excitatory and inhibitory interneurons during spinal cord development …

Context Change in ability realization reflects the main contribution of rehabilitation to
improvement in the performance of daily activities in patients with spinal cord lesions (SCL) …

Spinal cord injury (SCI) is a debilitating condition that is frequently accompanied by
neuropathic pain, resulting in significant physical and psychological harm to a vast number …

Each year approximately one million people suffer spinal cord injury, which has significant
physical, psychosocial and economic impacts on patients and their families. Spinal cord …