Background Opioid dependence is a chronic, relapsing disorder with important public health
implications. Methods In a 17-week randomized study of 220 patients, we compared …

Aim This study examines whether there is a minimum threshold, continuous or non‐linear
relationship between the duration of addiction treatment and improvements in drug use …

Purpose The American Society of Addiction Medicine (ASAM) developed the National
Practice Guideline for the Treatment of Opioid Use Disorder (the Practice Guideline) to …

Opioid use disorder is highly prevalent and can be fatal. At least 2.1 million Americans 12
years and older had opioid use disorder in 2016, and approximately 47,000 Americans died …

Rationale Laboratory animal and human models of drug self-administration are used to
evaluate potential pharmacotherapies for drug abuse, yet the utility of these models in …

The efficacy of methadone maintenance in opioid addiction was assessed in terms of
programme retention rate and reduction of illicit opioid use by means of a meta-analysis of …

While opioid dependence has more treatment agents available than other abused drugs,
none are curative. They can, however, markedly diminish withdrawal symptoms and craving …

Objective: To estimate, via meta-analysis, the influence of different methadone dose ranges
and dosing strategies on retention rates in methadone maintenance treatment (MMT) …

Background and Objective Recent in vitro studies have suggested an important role of
cytochrome P450 (CYP) 2B6 and CYP2C19 in methadone metabolism. We aimed to …

Background Sublingual formulations of buprenorphine (BUP) and BUP/naloxone have well-
established pharmacokinetic and pharmacodynamic profiles, and are safe and effective for …