Chronic neuropathic pain, the most frequent condition affecting the peripheral nervous
system, remains underdiagnosed and difficult to treat. Inhaled cannabis may alleviate …

Chronic pain is a debilitating clinical condition associated with a variety of disease entities
including diabetic neuropathy, postherpetic neuralgia, low back pathology, fibromyalgia, and …

Background The limitations of current treatments for postherpetic neuralgia (PHN) have led
to the investigation of localised, non-systemic alternatives. NGX-4010, a high-concentration …

The neurotransmitter serotonin (5-HT) plays an important role in both the peripheral and
central nervous systems. The biosynthesis of serotonin is regulated by two rate-limiting …

Although platinum-based cancer chemotherapies produce painful peripheral neuropathy as
dose-limiting side effects, there are important differences in the pain syndromes produced by …

Background In randomised studies, the capsaicin 8% patch has demonstrated effective pain
relief in patients with peripheral neuropathic pain (PNP) arising from different aetiologies …

Neuropathic pain is a considerable burden that affects activities of daily living. The
management of neuropathic pain can be challenging because of multiple etiologies and …

Recent scientific advances have enhanced our understanding of the role voltage-gated
sodium channels play in pain sensation. Human data on Nav1. 7 show that gain-of-function …

Cell death has been reported in the CNS in models of neuropathic pain (;;;). In our present
study, we examined the effects of spinal nerve ligation (SNL) on the number of neurons in …

Introduction: Chronic neuropathic pain is difficult to treat and is often refractory to most
modalities of treatment. Ziconotide is a novel, potent, non-opioid, calcium channel blocking …