In terrestrial vertebrates, bone tissue constitutes the 'osteoimmune'system, which functions
as a locomotor organ and a mineral reservoir as well as a primary lymphoid organ where …

Myelodysplastic syndromes (MDS) are characterized by ineffective hematopoiesis with
varying degrees of dysplasia and peripheral cytopenias. MDS are driven by structural …

Hematopoietic clones harboring specific mutations may expand over time. However, it
remains unclear how different cellular stressors influence this expansion. Here we …

Acute lymphoblastic leukemia (ALL) cells reside in the bone marrow microenvironment
which nurtures and protects cells from chemotherapeutic drugs. The disruption of cell-cell …

Relapse of acute leukemia following hematopoietic stem cell transplantation (HSCT) usually
represents return of an original disease clone, having evaded eradication by pretransplant …

Adequate recovery of hematopoietic stem cell (HSC) niches after cytotoxic conditioning
regimens is essential to successful bone marrow transplantation. Yet, very little is known …

Normal stem cell niches typically are identified by their distinctive anatomical features and
by association with tissue-specific stem cells. Identifying cancer stem cell (CSC) niches …

Acute leukemias are the most common cancer in childhood and characterized by the
uncontrolled production of hematopoietic precursor cells of the lymphoid or myeloid series …

Human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) provide
remarkable cellular platforms to better understand human hematopoiesis and to develop …

Melanoma, the deadliest skin cancer, remains largely incurable at advanced stages.
Currently, there is a lack of animal models that resemble human melanoma initiation and …