Vitamin D has a key role in stimulating calcium absorption from the gut and promoting
skeletal health, as well as many other important physiological functions. Vitamin D is …

Tissue repair is critical for animal survival. The skin epidermis is particularly exposed to
injuries, which necessitates rapid repair. The coordinated action of distinct epidermal stem …

The murine epidermis with its hair follicles represents an invaluable model system for tissue
regeneration and stem cell research. Here we used single-cell RNA-sequencing to reveal …

The skin, which serves as the first barrier of the human body, is particularly susceptible to
exogenous injuries. Skin wounds, including acute burns and chronic non-healing ulcers, are …

Podoplanin is a small cell-surface mucin-like glycoprotein that plays a crucial role in the
development of the alveoli, heart, and lymphatic vascular system. Emerging evidence …

Long considered both physiologic and inevitable, skin aging is a degenerative phenomenon
whereby both intrinsic and environmental factors conspire to produce an authentic disease …

Central to the classical hematopoietic stem cell (HSC) paradigm is the concept that the
maintenance of blood cell numbers is exclusively executed by a discrete physical entity: the …

Our skin is the largest organ of the body, serving as an important barrier against the harsh
extrinsic environment. Alongside preventing desiccation, chemical damage and …

Epithelial tissues line the outer surfaces of the mammalian body and protect from external
harm. In skin, the epithelium is maintained by distinct stem cell populations residing in the …

Mammalian skin research represents the convergence of three complementary disciplines:
cell biology, mouse genetics, and dermatology. The skin provides a paradigm for current …