Toward merging untargeted and targeted methods in mass spectrometry-based metabolomics and lipidomics

T Cajka, O Fiehn - Analytical chemistry, 2016 - ACS Publications
Advances in mass spectrometry (MS) and data processing have led to discoveries in
regulation of cellular metabolism by using metabolomics and lipidomics approaches. 1, 2 …

Metabolomics: a primer

X Liu, JW Locasale - Trends in biochemical sciences, 2017 - cell.com
Metabolomics generates a profile of small molecules that are derived from cellular
metabolism and can directly reflect the outcome of complex networks of biochemical …

Quality assurance procedures for mass spectrometry untargeted metabolomics. a review

D Dudzik, C Barbas-Bernardos, A García… - … of pharmaceutical and …, 2018 - Elsevier
Untargeted metabolomics, as a global approach, has already proven its great potential and
capabilities for the investigation of health and disease, as well as the wide applicability for …

Recent advances in LC‐MS‐based metabolomics for clinical biomarker discovery

CJ Chen, DY Lee, J Yu, YN Lin… - Mass spectrometry …, 2023 - Wiley Online Library
The employment of liquid chromatography‐mass spectrometry (LC‐MS) untargeted and
targeted metabolomics has led to the discovery of novel biomarkers and improved the …

Metabolomics: the apogee of the omics trilogy

GJ Patti, O Yanes, G Siuzdak - Nature reviews Molecular cell biology, 2012 - nature.com
Metabolites, the chemical entities that are transformed during metabolism, provide a
functional readout of cellular biochemistry. With emerging technologies in mass …

Nutrimetabolomics: an integrative action for metabolomic analyses in human nutritional studies

MM Ulaszewska, CH Weinert… - Molecular nutrition & …, 2019 - Wiley Online Library
The life sciences are currently being transformed by an unprecedented wave of
developments in molecular analysis, which include important advances in instrumental …

Procedures for large-scale metabolic profiling of serum and plasma using gas chromatography and liquid chromatography coupled to mass spectrometry

WB Dunn, D Broadhurst, P Begley, E Zelena… - Nature protocols, 2011 - nature.com
Metabolism has an essential role in biological systems. Identification and quantitation of the
compounds in the metabolome is defined as metabolic profiling, and it is applied to define …

The growing role of precision and personalized medicine for cancer treatment

P Krzyszczyk, A Acevedo, EJ Davidoff, LM Timmins… - Technology, 2018 - World Scientific
Cancer is a devastating disease that takes the lives of hundreds of thousands of people
every year. Due to disease heterogeneity, standard treatments, such as chemotherapy or …

Metabolomics analysis reveals large effects of gut microflora on mammalian blood metabolites

WR Wikoff, AT Anfora, J Liu… - Proceedings of the …, 2009 - National Acad Sciences
Although it has long been recognized that the enteric community of bacteria that inhabit the
human distal intestinal track broadly impacts human health, the biochemical details that …

Global metabolic profiling procedures for urine using UPLC–MS

EJ Want, ID Wilson, H Gika, G Theodoridis, RS Plumb… - Nature protocols, 2010 - nature.com
The production of'global'metabolite profiles involves measuring low molecular-weight
metabolites (< 1 kDa) in complex biofluids/tissues to study perturbations in response to …