Drug delivery to the lens for the management of cataracts

TR Thrimawithana, ID Rupenthal, SS Räsch… - Advanced drug delivery …, 2018 - Elsevier
Cataracts are one of the most prevalent diseases of the lens, affecting its transparency and
are the leading cause of reversible blindness in the world. The clarity of the lens is essential …

[HTML][HTML] Histopathological effects of ultraviolet radiation exposure on the ocular structures in animal studies–literature review

N Hamba, A Gerbi, S Tesfaye - Translational Research in Anatomy, 2021 - Elsevier
The transparent anterior segment of the human eye (cornea and lens), as well as neural
retina, are the principal target of UV radiation for both acute and long-term exposure. The …

The mechanism of UVB irradiation induced-apoptosis in cataract

Y Ji, L Cai, T Zheng, H Ye, X Rong, J Rao… - Molecular and Cellular …, 2015 - Springer
Cataract is the most common eye disease that causes blindness in patients. Ultraviolet B
(UVB) irradiation is considered an important factor leading to cataract by inducing apoptosis …

[HTML][HTML] UV light-blocking contact lenses protect against short-term UVB-induced limbal stem cell niche damage and inflammation

M Notara, S Behboudifard, MA Kluth, C Maßlo… - Scientific Reports, 2018 - nature.com
UVB irradiation has been linked to pathogenesis of pterygium, a conjunctival tumor growing
onto transparent cornea, the windscreen of the eye. Due to corneal anatomy, ambient UVB …

Tryptophan Cluster Protects Human γD‐Crystallin from Ultraviolet Radiation‐Induced Photoaggregation In Vitro

N Schafheimer, J King - Photochemistry and photobiology, 2013 - Wiley Online Library
Exposure to ultraviolet radiation (UVR) is a significant risk factor for age‐related cataract, a
disease of the human lens and the most prevalent cause of blindness in the world. Cataract …

The effect of topical piperine combined with narrowband UVB on vitiligo treatment: A clinical trial study

A Shafiee, M Hoormand… - Phytotherapy …, 2018 - Wiley Online Library
Vitiligo is the most common acquired hypopigmentary disease in the community. Piperine as
an herbal extract derived from black pepper has strong impact on the melanocyte …

Tyrosine/cysteine cluster sensitizing human γD-crystallin to ultraviolet radiation-induced photoaggregation in vitro

N Schafheimer, Z Wang, K Schey, J King - Biochemistry, 2014 - ACS Publications
Ultraviolet radiation (UVR) exposure is a major risk factor for age-related cataract, a protein-
aggregation disease of the human lens often involving the major proteins of the lens, the …

[HTML][HTML] UVB induces apoptosis via downregulation of CALML3-dependent JNK1/2 and ERK1/2 pathways in cataract

Y Jia, Q Qin, CP Fang, W Shen… - International …, 2018 - spandidos-publications.com
The aim of the current study was to understand the mechanisms of apoptosis occurring in
cultured human lens epithelial cells (HLECs) following ultraviolet B (UVB) irradiation. The …

Photosensitizing activity of endogenous eye lens chromophores: an attempt to unravel their contributions to photo‐aging and cataract disease

F Avila, B Friguet, E Silva - Photochemistry and Photobiology, 2015 - Wiley Online Library
UVA‐visible light has been proposed as a risk factor in the photo‐aging of the human eye
lens, as well as in the etiology of cataract disease. There is accumulating evidence …

[HTML][HTML] Poly (Sulfobetaine Methacrylate-co-Vinyl Pyrrolidone) Hydrogels as Potential Contact Lenses Delivery Systems for Timolol Maleate

D Nikolova, C Tzachev, L Christov, E Vassileva - Gels, 2023 - mdpi.com
The study reveals the development of novel hydrogels based on sulfobetaine methacrylate
(SB) and vinyl pyrrolidone (VP) copolymers as potential contact lenses delivery systems of …