Statin adverse effects: a review of the literature and evidence for a mitochondrial mechanism
BA Golomb, MA Evans - American Journal of Cardiovascular Drugs, 2008 - Springer
HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …
Mitochondria as a pharmacological target
A Szewczyk, L Wojtczak - Pharmacological reviews, 2002 - ASPET
Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …
dysfunctions lead to various neurodegenerative disorders and to the so-called …
Bioenergetics of immune functions: fundamental and therapeutic aspects
F Buttgereit, GR Burmester, MD Brand - Immunology today, 2000 - cell.com
Cellular energy metabolism is an important part of the background machinery that ensures
proper function of immune cells. Here, Frank Buttgereit and colleagues describe the …
proper function of immune cells. Here, Frank Buttgereit and colleagues describe the …
Amiodarone hepatotoxicity
M Babatin, SS Lee, PT Pollak - Current vascular pharmacology, 2008 - ingentaconnect.com
Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …
whether to initiate or continue treatment with this medication. While mostly associated with …
Identification of drugs inducing phospholipidosis by novel in vitro data
M Muehlbacher, P Tripal, F Roas… - ChemMedChem, 2012 - Wiley Online Library
Drug‐induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the
accumulation of phospholipids within the lysosome. This adverse drug effect can occur in …
accumulation of phospholipids within the lysosome. This adverse drug effect can occur in …
Disruption of mitochondrial function and cellular ATP levels by amiodarone and N-desethylamiodarone in initiation of amiodarone-induced pulmonary cytotoxicity
MW Bolt, JW Card, WJ Racz, JF Brien… - Journal of Pharmacology …, 2001 - ASPET
Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …
Differential effects of pirfenidone on acute pulmonary injury and ensuing fibrosis in the hamster model of amiodarone-induced pulmonary toxicity
JW Card, WJ Racz, JF Brien, SB Margolin… - Toxicological …, 2003 - academic.oup.com
Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …
Attenuation of amiodarone-induced pulmonary fibrosis by vitamin E is associated with suppression of transforming growth factor-β1 gene expression but not …
JW Card, WJ Racz, JF Brien, TE Massey - Journal of Pharmacology and …, 2003 - ASPET
Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse
effects, including potentially life-threatening pulmonary fibrosis. The current study was …
effects, including potentially life-threatening pulmonary fibrosis. The current study was …
miR-155 influences cell-mediated immunity in Balb/c mice treated with aflatoxin M1
Abstract Aflatoxin M1 (AFM1) is a 4-hydroxylated metabolite of aflatoxin B1 (AFB1). It
induces various toxicological effects including immunotoxicity. In the present study, we …
induces various toxicological effects including immunotoxicity. In the present study, we …
Interaction with the hERG channel and cytotoxicity of amiodarone and amiodarone analogues
KM Waldhauser, K Brecht, S Hebeisen… - British journal of …, 2008 - Wiley Online Library
Background and purpose: Amiodarone (2‐n‐butyl‐3‐[3, 5 diiodo‐4‐
diethylaminoethoxybenzoyl]‐benzofuran, B2‐O‐CH2CH2‐N‐diethyl) is an effective class III …
diethylaminoethoxybenzoyl]‐benzofuran, B2‐O‐CH2CH2‐N‐diethyl) is an effective class III …