HMG-CoA reductase inhibitors (statins) are a widely used class of drug, and like all
medications, have potential for adverse effects (AEs). Here we review the statin AE literature …

Mitochondria play a central role in energy metabolism within the cell. Mitochondrial
dysfunctions lead to various neurodegenerative disorders and to the so-called …

Cellular energy metabolism is an important part of the background machinery that ensures
proper function of immune cells. Here, Frank Buttgereit and colleagues describe the …

Potential hepatotoxicity related to amiodarone therapy is often a concern when deciding
whether to initiate or continue treatment with this medication. While mostly associated with …

Drug‐induced phospholipidosis (PLD) is a lysosomal storage disorder characterized by the
accumulation of phospholipids within the lysosome. This adverse drug effect can occur in …

Amiodarone (AM), a potent antidysrhythmic agent, can cause potentially life-threatening
pulmonary fibrosis. In the present investigation of mechanisms of initiation of AM lung …

Pulmonary toxicity, including fibrosis, is a serious adverse effect associated with the
antidysrhythmic drug amiodarone (AM). We tested the potential usefulness of pirfenidone …

Amiodarone (AM) is an efficacious antidysrhythmic agent that can cause numerous adverse
effects, including potentially life-threatening pulmonary fibrosis. The current study was …

Abstract Aflatoxin M1 (AFM1) is a 4-hydroxylated metabolite of aflatoxin B1 (AFB1). It
induces various toxicological effects including immunotoxicity. In the present study, we …

Background and purpose: Amiodarone (2‐n‐butyl‐3‐[3, 5 diiodo‐4‐
diethylaminoethoxybenzoyl]‐benzofuran, B2‐O‐CH2CH2‐N‐diethyl) is an effective class III …