Accumulating evidence shows that cellular and acellular components in tumor
microenvironment (TME) can reprogram tumor initiation, growth, invasion, metastasis, and …

Tumor microenvironment (TME) is a specialized ecosystem of host components, designed
by tumor cells for successful development and metastasis of tumor. With the advent of 3D …

Regulatory T (Treg) cells, although vital for immune homeostasis, also represent a major
barrier to anti-cancer immunity, as the tumour microenvironment (TME) promotes the …

In the early 1920s, Warburg published experimental data on the enhanced conversion of
glucose to pyruvate (followed by lactate formation) even in the presence of abundant oxygen …

During an inflammatory process, shift in the cellular metabolism associated with an increase
in extracellular acidification are well-known features. This pH drop in the inflamed tissue is …

Characterized by the expression of the critical transcription factor forkhead box protein P3,
regulatory T (Treg) cells are an essential part of the immune system, with a dual effect on the …

Neutrophils act as the first line of defense against invading pathogens. Although traditionally
considered in context of their antimicrobial effector functions, the importance of tumor …

Many tumors evolve sophisticated strategies to evade the immune system, and these
represent major obstacles for efficient antitumor immune responses. Here we explored a …

Simple Summary The role of lactate in cancer described by Otto Warburg in 1927 states that
cancer cells uptake high amount of glucose with a marked increase in lactate production …

Reprogramming of biochemical pathways is a hallmark of cancer cells, and generation of
lactic acid from glucose/glutamine represents one of the consequences of such metabolic …