Anticancer drugs are not purely effective because of their toxicity, side effects, high cost,
inaccessibility, and associated resistance. On the other hand, cancer is a complex public …

Pancreatic ductal adenocarcinoma (PDA) is an aggressive cancer that is highly refractory to
the current standards of care. The difficulty in treating this disease is due to a number of …

Carriers of heterozygous germline BAP1 mutations (BAP1+/−) develop cancer. We studied
plasma from 16 BAP1+/− individuals from 2 families carrying different germline BAP1 …

Background and Aims Pyruvate kinase M2 (PKM2) is an essential regulator of the Warburg
effect, but its biological function promoting immune escape of hepatocellular carcinoma …

Integrins are important regulators of cell survival, proliferation, adhesion and migration.
Once activated, integrins establish a regulated link between the extracellular matrix and the …

Simple Summary Renal cell carcinoma is particularly characterized by its high
vascularization and dense immune cells infiltration. The angiogenesis blockade in …

In the last few decades, the role of cancer stem cells in initiating tumors, metastasis,
invasion, and resistance to therapies has been recognized as a potential target for tumor …

Despite significant advances of nanomedicine, the issues of biocompatibility, accumulation-
derived toxicity, and the lack of sensing and in vivo imaging capabilities hamper the …

Monocarboxylate transporters (MCTs) represent a diverse group of transmembrane proteins
encoded by the SLC16 gene family found ubiquitously across mammalian species. Two …

Aerobic glycolysis is a recognized feature shared by tumors, leading to the accumulation of
lactic acid in their local microenvironments. Like the tumors, the blastocysts, placenta …