Colorectal Cancer (CRC) is a major cause of cancer-related death worldwide. CRC
increased risk has been associated with alterations in the intestinal microbiota, with …

Transforming Growth Factor-β (TGF-β) is a key regulator of embryonic development, adult
tissue homeostasis, and lesion repair. In tumors, TGF-β is a potent inhibitor of early stage …

Hypoxia‐inducible factor‐1alpha (HIF‐1α) is a major transcription factor that adapts to low
oxygen homeostasis and regulates the expression of several hypoxic genes, which aid in …

Breast cancer is the most frequent tumor and the leading cause of cancer deaths in women.
In recent years, lactate metabolism and, in particular, its receptor GPR81 have been shown …

Increasing body of evidence suggests that there exists a connection between diabetes and
cancer. Nevertheless, to date, the potential reasons for this association are still poorly …

Mitochondrial dysfunction is a key feature of cancer and is frequently associated with
increased aggressiveness and metastatic potential. Recent evidence has brought to light a …

Over the past 15 years, mesenchymal stem cells (MSCs) have been assessed for their
capacity to suppress inflammation and promote tissue repair. Regardless of whether the …

Lactate is the main product generated at the end of anaerobic glycolysis or during the
Warburg effect and its role as an active signalling molecule is increasingly recognised …

Immunotherapies are revolutionizing the clinical management of a wide range of cancers.
However, intrinsic or acquired unresponsiveness to immunotherapies does occur due to the …

Alpha linolenic acid is an essential polyunsaturated fatty acid and is reported to have the
anti-cancer potential with no defined hypothesis or mechanism/s. Henceforth present study …