T cell immunoreceptor with Ig and ITIM domains (TIGIT) is an inhibitory receptor expressed
on several types of lymphocytes. Efficacy of antibody blockade of TIGIT in cancer …

Targeting immune checkpoints such as programmed cell death protein 1 (PD1),
programmed cell death 1 ligand 1 (PDL1) and cytotoxic T lymphocyte antigen 4 (CTLA4) has …

T cell Ig and ITIM domain (TIGIT) is an inhibitory receptor expressed by activated T cells,
Tregs, and NK cells. Here, we determined that TIGIT is upregulated on tumor antigen …

The use of inhibitory checkpoint blockade in the management of glioblastoma has been
studied in both preclinical and clinical settings. TIGIT is a novel checkpoint inhibitor recently …

Natural killer (NK) cells are innate lymphocytes that are crucial for the control of infections
and malignancies. NK cells express a variety of inhibitory and activating receptors that …

Natural killer (NK) cells are lymphocytes of the innate immune response characterized by
their role in the destruction of tumor cells. Activation of NK cells depend on a fine balance …

Simple Summary The estimated survival time for glioblastoma patients is extremely low; only
about 5% of patients survive five years post diagnosis. The standard of care for glioblastoma …

In recent years, roles of the immune system in immune surveillance of cancer have been
explored using a variety of approaches. The roles of the adaptive immune system have been …

NK cell cytotoxicity is controlled by numerous NK inhibitory and activating receptors. Most of
the inhibitory receptors bind MHC class I proteins and are expressed in a variegated …

Small cell lung cancer (SCLC; accounting for approximately 13%–15% of all lung cancers)
is an exceptionally lethal malignancy characterized by rapid doubling time and high …