Biocompatible long-sustained release oil-core polyelectrolyte nanocarriers: From controlling physical state and stability to biological impact

K Szczepanowicz, U Bazylińska, J Pietkiewicz… - Advances in Colloid and …, 2015 - Elsevier
It has been generally expected that the most applicable drug delivery system (DDS) should
be biodegradable, biocompatible and with incidental adverse effects. Among many micellar …

Nanostructured multilayer polyelectrolyte films with silver nanoparticles as antibacterial coatings

T Kruk, K Szczepanowicz, D Kręgiel… - Colloids and Surfaces B …, 2016 - Elsevier
Ultrathin polyelectrolyte films containing silver nanoparticles appear to be a promising
material for antimicrobial coatings used in the medical area. The present work is focused on …

In vivo studies on pharmacokinetics, toxicity and immunogenicity of polyelectrolyte nanocapsules functionalized with two different polymers: poly-L-glutamic acid or …

A Karabasz, K Szczepanowicz, A Cierniak… - International Journal …, 2019 - Taylor & Francis
Background The functionalization of a nanoparticle surface with PEG (polyethylene glycol) is
an approach most often used for extending nanomaterial circulation time, enhancing its …

Blood-compatible, stable micelles of sodium alginate–curcumin bioconjugate for anti-cancer applications

D Lachowicz, A Karabasz, M Bzowska… - European Polymer …, 2019 - Elsevier
The bioconjugate of alginate and curcumin (AA-CUR) was synthesized in a simple, one-step
process and used to prepare the stable calcium cross-linked spherical micelles serving as a …

Pegylated polyelectrolyte nanoparticles containing paclitaxel as a promising candidate for drug carriers for passive targeting

K Szczepanowicz, M Bzowska, T Kruk… - Colloids and Surfaces B …, 2016 - Elsevier
Targeted drug delivery systems are of special importance in cancer therapies, since serious
side effects resulting from unspecific accumulation of highly toxic chemotherapeutics in …

[HTML][HTML] New SDS-based polyelectrolyte multicore nanocarriers for paclitaxel delivery—synthesis, characterization, and activity against breast cancer cells

M Szwed, S Michlewska, K Kania, M Szczęch… - Cells, 2023 - mdpi.com
The low distribution of hydrophobic anticancer drugs in patients is one of the biggest
limitations during conventional chemotherapy. SDS-based polyelectrolyte multicore …

Hybrid Polyelectrolyte/Fe3O4 Nanocapsules for Hyperthermia Applications

L Cristofolini, K Szczepanowicz, D Orsi… - Acs Applied Materials …, 2016 - ACS Publications
We validated here the applicability to hyperthermia treatment of magnetic nanocapsules
prepared by the sequential layer-by-layer adsorption of polyelectrolytes and magnetic …

In vitro toxicity studies of biodegradable, polyelectrolyte nanocapsules

A Karabasz, K Szczepanowicz, A Cierniak… - International Journal …, 2018 - Taylor & Francis
Background Toxicity of nanomaterials is one of the most important factors limiting their
medical application. Evaluation of in vitro nanotoxicity allows for the identification and …

Encapsulation of clozapine in polymeric nanocapsules and its biological effects

S Łukasiewicz, K Szczepanowicz, K Podgórna… - Colloids and Surfaces B …, 2016 - Elsevier
Clozapine is an effective atypical antipsychotic drug that unfortunately exhibits poor oral
bioavailability. Moreover, the clinical use of the compound is limited because of its …

[HTML][HTML] Biocompatible oil core nanocapsules as potential co-carriers of paclitaxel and fluorescent markers: preparation, characterization, and bioimaging

S Drozdek, U Bazylińska - Colloid and polymer science, 2016 - Springer
The present work is focused on the long-term stability and in vitro cellular internalization of
newly designed biocompatible polyester nanocapsules prepared via nanoprecipitation …