Cellular mechanotransduction in health and diseases: from molecular mechanism to therapeutic targets
Cellular mechanotransduction, a critical regulator of numerous biological processes, is the
conversion from mechanical signals to biochemical signals regarding cell activities and …
conversion from mechanical signals to biochemical signals regarding cell activities and …
Traditional Chinese Medicine has great potential as candidate drugs for lung cancer: A review
Z Wei, J Chen, F Zuo, J Guo, X Sun, D Liu… - Journal of …, 2023 - Elsevier
Ethnopharmacological relevance With high mortality and morbidity rates, lung cancer (LC)
has become one of the major threats to human health. The treatment strategies for LC …
has become one of the major threats to human health. The treatment strategies for LC …
Research progress in the molecular mechanisms, therapeutic targets, and drug development of idiopathic pulmonary fibrosis
H Ma, X Wu, Y Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease. Recent studies have
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …
identified the key role of crosstalk between dysregulated epithelial cells, mesenchymal …
Role of IL-17 family cytokines in the progression of IPF from inflammation to fibrosis
YJ Nie, SH Wu, YH Xuan, G Yan - Military Medical Research, 2022 - Springer
Idiopathic pulmonary fibrosis (IPF) is a fatal chronic interstitial lung disease with no
established treatment and is characterized by progressive scarring of the lung tissue and an …
established treatment and is characterized by progressive scarring of the lung tissue and an …
[HTML][HTML] The role of IL-6 in fibrotic diseases: molecular and cellular mechanisms
Y Li, J Zhao, Y Yin, K Li, C Zhang… - International journal of …, 2022 - ncbi.nlm.nih.gov
Fibrosis is a detrimental outcome of most chronic inflammatory disorders and is defined by
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …
the buildup of excess extracellular matrix (ECM) components, which eventually leads to …
Role of protein phosphorylation in cell signaling, disease, and the intervention therapy
K Pang, W Wang, JX Qin, ZD Shi, L Hao, YY Ma… - MedComm, 2022 - Wiley Online Library
Protein phosphorylation is an important post‐transcriptional modification involving an
extremely wide range of intracellular signaling transduction pathways, making it an …
extremely wide range of intracellular signaling transduction pathways, making it an …
Targeting growth factor and cytokine pathways to treat idiopathic pulmonary fibrosis
H Ma, S Liu, S Li, Y Xia - Frontiers in Pharmacology, 2022 - frontiersin.org
Idiopathic pulmonary fibrosis (IPF) is a chronic interstitial lung disease of unknown origin
that usually results in death from secondary respiratory failure within 2–5 years of diagnosis …
that usually results in death from secondary respiratory failure within 2–5 years of diagnosis …
Canonical and noncanonical regulatory roles for JAK2 in the pathogenesis of rheumatoid arthritis‐associated interstitial lung disease and idiopathic pulmonary …
S Wang, M Liu, X Li, J Zhang, F Wang… - The FASEB …, 2022 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) and rheumatoid arthritis‐associated interstitial lung
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
disease (RA‐ILD) are two fibrotic interstitial lung diseases that share the usual interstitial …
Natural plant resource flavonoids as potential therapeutic drugs for pulmonary fibrosis
MC Wang - Heliyon, 2023 - cell.com
Pulmonary fibrosis is an enduring and advancing pulmonary interstitial disease caused by
multiple factors that ultimately lead to structural changes in normal lung tissue. Currently …
multiple factors that ultimately lead to structural changes in normal lung tissue. Currently …
[HTML][HTML] Pirfenidone ameliorates pulmonary inflammation and fibrosis in a rat silicosis model by inhibiting macrophage polarization and JAK2/STAT3 signaling …
Q Tang, C Xing, M Li, Q Jia, C Bo, Z Zhang - … and environmental safety, 2022 - Elsevier
Macrophages play an important role in causing silicosis eventually becoming an irreversible
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …
fibrotic disease, and there are no specific drugs for silicosis in the clinic so far. Pirfenidone …