In the last few years, more and more scientists have suggested and confirmed that
epigenetic regulators are tightly connected and form a comprehensive network of regulatory …

Both genetic and epigenetic mechanisms intimately regulate cancer development and
chemoresistance. Different genetic alterations are observed in multiple genes, and most are …

Colorectal cancer is one of the most common cancers in the world. Although genomic
mutations and single nucleotide polymorphisms have been extensively studied, the …

Lung squamous cell carcinoma (LUSC) represents a major subtype of lung cancer with
limited treatment options. KMT2D is one of the most frequently mutated genes in LUSC (> …

The epigenetic regulator, MLL4 (KMT2D), has been described as an essential gene in both
humans and mice. In addition, it is one of the most commonly mutated genes in all of cancer …

Mesenchymal stem cells (mesenchymal stromal cells, MSC) are multipotent stem cells that
can differentiate into cells of at least three mesodermal lineages, namely adipocytes …

Background Frequent truncation mutations of the histone lysine N-methyltransferase KMT2C
have been detected by whole exome sequencing studies in various cancers, including …

Peripheral T-cell lymphoma (PTCL) is a rare and heterogeneous group of clinically
aggressive diseases associated with poor prognosis. Except for ALK+ anaplastic large-cell …

In some types of cancer, telomere length is maintained by the alternative lengthening of
telomeres (ALT) mechanism. In many ALT cancers, the α‐thalassemia/mental retardation …

Enhancers are cis-regulatory elements that play essential roles in tissue-specific gene
expression during development. Enhancer function in the expression of developmental …