Central nervous system (CNS) disorders affect as many as 1.5 billion people globally. The
limited delivery of most imaging and therapeutic agents into the brain is a major challenge …

Epileptogenesis is a chronic process that can be triggered by genetic or acquired factors,
and that can continue long after epilepsy diagnosis. In 2015, epileptogenesis is not a …

The perpetual activity of the cerebral cortex is largely supported by the variety of oscillations
the brain generates, spanning a number of frequencies and anatomical locations, as well as …

Our understanding of BBB breakdown acutely after the cerebrovascular injury has come a
long way; however, we lack a clear understanding of the course of BBB disruption and BBB …

There is ample empirical evidence to support the notion that the biological impacts of
estrogen extend beyond the gonads to other bodily systems, including the brain and …

Cyclooxygenases (COXs) oxidize arachidonic acid to prostaglandin (PG) G 2 and H 2
followed by PG synthases that generates PGs and thromboxane (TX) A 2. COXs are divided …

Despite advancements in understanding the pathophysiology of stroke and the state of the
art in acute management of afflicted patients as well as in subsequent neurorehabilitation …

Acute central nervous system injury, encompassing traumatic brain injury (TBI) and stroke,
accounts for a significant burden of morbidity and mortality worldwide. Studies in animal …

Despite the impressive efficacies demonstrated in preclinical research, hundreds of
potentially neuroprotective drugs have failed to provide effective neuroprotection for …

Radiotherapy (RT) is a cornerstone treatment strategy for brain tumours. Besides
cytotoxicity, RT can cause disruption of the blood–brain barrier (BBB), resulting in an …