[HTML][HTML] Amyloid β-based therapy for Alzheimer's disease: Challenges, successes and future

Y Zhang, H Chen, R Li, K Sterling… - Signal transduction and …, 2023 - nature.com
Amyloid β protein (Aβ) is the main component of neuritic plaques in Alzheimer's disease
(AD), and its accumulation has been considered as the molecular driver of Alzheimer's …

[HTML][HTML] Alzheimer disease: an update on pathobiology and treatment strategies

JM Long, DM Holtzman - Cell, 2019 - cell.com
Alzheimer disease (AD) is a heterogeneous disease with a complex pathobiology. The
presence of extracellular β-amyloid deposition as neuritic plaques and intracellular …

[HTML][HTML] Alzheimer's disease-associated β-amyloid is rapidly seeded by herpesviridae to protect against brain infection

WA Eimer, DKV Kumar, NKN Shanmugam… - Neuron, 2018 - cell.com
Amyloid-β peptide (Aβ) fibrilization and deposition as β-amyloid are hallmarks of Alzheimer's
disease (AD) pathology. We recently reported Aβ is an innate immune protein that protects …

[HTML][HTML] The antimicrobial protection hypothesis of Alzheimer's disease

RD Moir, R Lathe, RE Tanzi - Alzheimer's & Dementia, 2018 - Elsevier
Objective We explore here a novel model for amyloidogenesis in Alzheimer's disease (AD).
This new perspective on AD amyloidosis seeks to provide a rational framework for …

Amyloid-β peptide protects against microbial infection in mouse and worm models of Alzheimer's disease

DKV Kumar, SH Choi, KJ Washicosky… - Science translational …, 2016 - science.org
The amyloid-β peptide (Aβ) is a key protein in Alzheimer's disease (AD) pathology. We
previously reported in vitro evidence suggesting that Aβ is an antimicrobial peptide. We …

[HTML][HTML] The physiological roles of amyloid-β peptide hint at new ways to treat Alzheimer's disease

HM Brothers, ML Gosztyla… - Frontiers in aging …, 2018 - frontiersin.org
Amyloid-ß (Aß) is best known as the misfolded peptide that is involved in the pathogenesis
of Alzheimer's disease (AD), and it is currently the primary therapeutic target in attempts to …

Microbes and Alzheimer's disease

RF Itzhaki, R Lathe, BJ Balin, MJ Ball… - … of Infection and …, 2017 - ebooks.iospress.nl
We are researchers and clinicians working on Alzheimer's disease (AD) or related topics,
and we write to express our concern that one particular aspect of the disease has been …

[HTML][HTML] Self-assembling dipeptide antibacterial nanostructures with membrane disrupting activity

L Schnaider, S Brahmachari, NW Schmidt… - Nature …, 2017 - nature.com
Peptide-based supramolecular assemblies are a promising class of nanomaterials with
important biomedical applications, specifically in drug delivery and tissue regeneration …

[HTML][HTML] Herpes simplex virus-1 in the brain: the dark side of a sneaky infection

ME Marcocci, G Napoletani, V Protto, O Kolesova… - Trends in …, 2020 - cell.com
Herpes simplex virus-1 (HSV-1) establishes latency preferentially in sensory neurons of
peripheral ganglia. A variety of stresses can induce recurrent reactivations of the virus …

The role of astrocytes in amyloid production and Alzheimer's disease

GR Frost, YM Li - Open biology, 2017 - royalsocietypublishing.org
Alzheimer's disease (AD) is marked by the presence of extracellular amyloid beta (Aβ)
plaques, intracellular neurofibrillary tangles (NFTs) and gliosis, activated glial cells, in the …