[HTML][HTML] Human herpesvirus 6 detection in Alzheimer's disease cases and controls across multiple cohorts
MA Allnutt, K Johnson, DA Bennett, SM Connor… - Neuron, 2020 - cell.com
The interplay between viral infection and Alzheimer's disease (AD) has long been an area of
interest, but proving causality has been elusive. Several recent studies have renewed the …
interest, but proving causality has been elusive. Several recent studies have renewed the …
[HTML][HTML] Microbial infections are a risk factor for neurodegenerative diseases
SK Lotz, BM Blackhurst, KL Reagin… - Frontiers in Cellular …, 2021 - frontiersin.org
Neurodegenerative diseases, such as Alzheimer's disease, Parkinson's disease, and
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …
amyotrophic lateral sclerosis, comprise a family of disorders characterized by progressive …
Role of the peripheral innate immune system in the development of Alzheimer's disease
Alzheimer's disease is one of the most devastating neurodegenerative diseases. The exact
cause of the disease is still not known although many scientists believe in the beta amyloid …
cause of the disease is still not known although many scientists believe in the beta amyloid …
[HTML][HTML] Molecular mechanisms for herpes simplex virus type 1 pathogenesis in Alzheimer's disease
SA Harris, EA Harris - Frontiers in aging neuroscience, 2018 - frontiersin.org
This review focuses on research in the areas of epidemiology, neuropathology, molecular
biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative …
biology and genetics that implicates herpes simplex virus type 1 (HSV-1) as a causative …
Protective effect of amyloid-β peptides against herpes simplex virus-1 infection in a neuronal cell culture model
Senile amyloid plaques are one of the main hallmarks of Alzheimer's disease (AD). They
correspond to insoluble deposits of amyloid-ß peptides (Aß) and are responsible for the …
correspond to insoluble deposits of amyloid-ß peptides (Aß) and are responsible for the …
[HTML][HTML] Physiological roles of monomeric amyloid-β and implications for Alzheimer's disease therapeutics
Alzheimer's disease (AD) progressively inflicts impairment of synaptic functions with notable
deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain …
deposition of amyloid-β (Aβ) as senile plaques within the extracellular space of the brain …
From inflamm-aging to immune-paralysis: a slippery slope during aging for immune-adaptation
T Fulop, G Dupuis, S Baehl, A Le Page, K Bourgade… - Biogerontology, 2016 - Springer
Aging is accompanied by many physiological changes including those in the immune
system. These changes are designated as immunosenescence indicating that age induces …
system. These changes are designated as immunosenescence indicating that age induces …
A mechanistic survey of Alzheimer's disease
Alzheimer's disease (AD) is the most common, age-dependent neurodegenerative disorder.
While AD has been intensively studied from different aspects, there is no effective cure for …
While AD has been intensively studied from different aspects, there is no effective cure for …
Human herpesviruses 6A and 6B in brain diseases: association versus causation
AL Komaroff, PE Pellett, S Jacobson - Clinical microbiology …, 2020 - Am Soc Microbiol
SUMMARY Human herpesvirus 6A (HHV-6A) and human herpesvirus 6B (HHV-6B),
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …
collectively termed HHV-6A/B, are neurotropic viruses that permanently infect most humans …
[HTML][HTML] Amyloid, tau, pathogen infection and antimicrobial protection in Alzheimer's disease–conformist, nonconformist, and realistic prospects for AD pathogenesis
Background Alzheimer's disease (AD) is a fatal disease that threatens the quality of life of an
aging population at a global scale. Various hypotheses on the etiology of AD have been …
aging population at a global scale. Various hypotheses on the etiology of AD have been …