Support for the concept that herpes simplex virus type 1 (HSV1), when present in the brains
of apolipoprotein E‐«4 carriers, is a major risk for Alzheimer's disease (AD) is increasing …

This article reviews research results and ideas presented at a special symposium at the
International Association of Gerontology and Geriatrics (IAGG) Congress held in July 2017 …

Amyloid-β (Aβ) accumulation is one of the cardinal pathological hallmarks of Alzheimer's
disease and plays an important role in its pathogenesis. Although the neurotoxic effects of …

The association between periodontal disease and systemic disease has become a research
hotspot. Porphyromonas gingivalis (P. gingivalis), a crucial periodontal pathogen, affects the …

Peptides with broad-spectrum antimicrobial activity are found widely expressed throughout
nature. As they participate in a number of different aspects of innate immunity in mammals …

We investigated the association between herpes zoster (HZ) and dementia, and the effects
of antiviral therapy on the risk of dementia. We used the National Health Insurance Service …

Periodontal disease is of established etiology in which polymicrobial synergistic ecology has
become dysbiotic under the influence of Porphyromonas gingivalis. Following breakdown of …

Background: Several environmental factors, including infectious agents, have been
suggested to cause Alzheimer's disease (AD). Cytomegalovirus (CMV) has been associated …

Amyloid plaques are a pathological hallmark of Alzheimer's disease. The major component
of these plaques are highly ordered amyloid fibrils formed by amyloid-β (Aβ) peptides …

COVID-19 and especially Long COVID are associated with severe CNS symptoms and may
place persons at risk to develop long-term cognitive impairments. Here, we show that two …