Neuroprotective effects of lactoferrin in Alzheimer's and Parkinson's diseases: A narrative review

SJ Yong, A Veerakumarasivam, WL Lim… - ACS Chemical …, 2023 - ACS Publications
Recent advancements in lactoferrin research have uncovered that lactoferrin does function
not only as an antimicrobial protein but also as an immunomodulatory, anticancer, and …

Viral involvement in Alzheimer's disease

A Sait, C Angeli, AJ Doig, PJR Day - ACS chemical neuroscience, 2021 - ACS Publications
Alzheimer's disease (AD) is characterized by the presence of β-amyloid plaques (Aβ) and
neurofibrillary tangles (NFTs) in the brain. The prevalence of the disease is increasing and is …

The Cryo-EM structures of two amphibian antimicrobial cross-β amyloid fibrils

R Bücker, C Seuring, C Cazey, K Veith… - Nature …, 2022 - nature.com
The amyloid-antimicrobial link hypothesis is based on antimicrobial properties found in
human amyloids involved in neurodegenerative and systemic diseases, along with …

Depletion of NK cells improves cognitive function in the Alzheimer disease mouse model

Y Zhang, ITH Fung, P Sankar, X Chen… - The Journal of …, 2020 - journals.aai.org
Despite mounting evidence suggesting the involvement of the immune system in regulating
brain function, the specific role of immune and inflammatory cells in neurodegenerative …

HHV-6A infection induces amyloid-beta expression and activation of microglial cells

D Bortolotti, V Gentili, A Rotola, E Caselli… - Alzheimer's research & …, 2019 - Springer
Background The control of viral infections in the brain involves the activation of microglial
cells, the macrophages of the brain that are constantly surveying the central nervous system …

The role of antimicrobial peptides in influenza virus infection and their potential as antiviral and immunomodulatory therapy

IN Hsieh, KL Hartshorn - Pharmaceuticals, 2016 - mdpi.com
Influenza A virus (IAV) remains a major threat that can cause severe morbidity and mortality
due to rapid genomic variation. Resistance of IAVs to current anti-IAV drugs has been …

Controversial properties of amyloidogenic proteins and peptides: new data in the COVID era

A Surguchov, FN Emamzadeh, M Titova, AA Surguchev - Biomedicines, 2023 - mdpi.com
For a long time, studies of amyloidogenic proteins and peptides (amyloidogenic PPs) have
been focused basically on their harmful properties and association with diseases. A vast …

Indication of neurodegenerative cascade initiation by amyloid-like aggregate-forming EBV proteins and peptide in Alzheimer's disease

D Tiwari, VK Singh, B Baral, DK Pathak… - ACS Chemical …, 2021 - ACS Publications
The neurotropic potential of the Epstein-Barr virus (EBV) was demonstrated quite recently;
however, the mechanistic details are yet to be explored. Therefore, the effects of EBV …

The increased amyloidogenicity of spike RBD and pH-dependent binding to ACE2 may contribute to the transmissibility and pathogenic properties of SARS-CoV-2 …

AY Aksenova, IV Likhachev, SY Grishin… - International Journal of …, 2022 - mdpi.com
SARS-CoV-2 is a rapidly evolving pathogen that has caused a global pandemic
characterized by several consecutive waves. Based on epidemiological and NGS data …

Insights into the potential role of mercury in Alzheimer's disease

G Bjørklund, AA Tinkov, M Dadar, MM Rahman… - Journal of Molecular …, 2019 - Springer
Mercury (Hg), which is a non-essential element, is considered a highly toxic pollutant for
biological systems even when present at trace levels. Elevated Hg exposure with the …