Targeting impaired antimicrobial immunity in the brain for the treatment of Alzheimer's disease

T Fulop, S Tripathi, S Rodrigues… - Neuropsychiatric …, 2021 - Taylor & Francis
Alzheimer's disease (AD) is the most common form of dementia and aging is the most
common risk factor for developing the disease. The etiology of AD is not known but AD may …

Peripheral immune signatures in Alzheimer disease

D Goldeck, JM Witkowski, T Fülop… - Current Alzheimer …, 2016 - ingentaconnect.com
According to the current paradigm, the main cause of AD is the accumulation of neurotoxic
amyloid beta (Aβ) peptide aggregates resulting from the cleavage of the amyloid precursor …

Regulatory roles of antimicrobial peptides in the nervous system: implications for neuronal aging

BAR Stuart, AL Franitza, LE - Frontiers in Cellular Neuroscience, 2022 - frontiersin.org
Antimicrobial peptides (AMPs) are classically known as important effector molecules in
innate immunity across all multicellular organisms. However, emerging evidence begins to …

Peripheral pathways to neurovascular unit dysfunction, cognitive impairment, and Alzheimer's Disease

AR Nelson - Frontiers in aging neuroscience, 2022 - frontiersin.org
Alzheimer's disease (AD) is the most common form of dementia. It was first described more
than a century ago, and scientists are acquiring new data and learning novel information …

Aβ Peptide Originated from Platelets Promises New Strategy in Anti‐Alzheimer's Drug Development

MY Inyushin, P Sanabria, L Rojas… - BioMed research …, 2017 - Wiley Online Library
The amyloid beta (Aβ) peptide and its deposits in the brain are known to be implicated in the
neurodegeneration that occurs during Alzheimer's disease (AD). Recently, alternative …

Design and engineering of amyloid aggregation‐prone fragments and their antimicrobial conjugates with multi‐target functionality

Y Zhang, Y Tang, Y Liu, D Zhang… - Advanced Functional …, 2021 - Wiley Online Library
Amyloid aggregation and microbial infection are considered major risk factors for
neurodegeneration and neuroinflammation in protein misfolding diseases (PMDs), including …

'Evolutionary medicine'perspectives on Alzheimer's Disease: Review and new directions

M Fox - Ageing research reviews, 2018 - Elsevier
Evolution by natural selection eliminates maladaptive traits from a species, and yet
Alzheimer's Disease (AD) persists with rapidly increasing prevalence globally. This apparent …

The role of chronic infection in Alzheimer's disease: instigators, co-conspirators, or bystanders?

L Butler, KA Walker - Current clinical microbiology reports, 2021 - Springer
Abstract Purpose of Review Herein, we provide a critical review of the clinical and
translational research examining the relationship between viral and bacterial pathogens and …

Herpes simplex virus alters Alzheimer's disease biomarkers‐A hypothesis paper

O Goldhardt, R Freiberger, T Dreyer… - Alzheimer's & …, 2023 - Wiley Online Library
Introduction Human herpes simplex virus 1 (HSV1) is discussed to induce amyloid‐β (Aβ)
accumulation and neurofibrillary tangles of hyperphosphorylated tau (pTau) in Alzheimer's …

Accumulation of amyloid beta in human glioblastomas

A Zayas-Santiago, A Díaz-García… - Clinical & …, 2020 - academic.oup.com
Many cancer types are intrinsically associated with specific types of amyloidosis, in which
amyloid is accumulated locally inside tumors or systemically. Usually, this condition relates …