Gastric Cancer in the Era of Epigenetics

G Christodoulidis, KE Koumarelas, MN Kouliou… - International Journal of …, 2024 - mdpi.com
Gastric cancer (GC) remains a significant contributor to cancer-related mortality. Novel high-
throughput techniques have enlightened the epigenetic mechanisms governing gene …

The emerging role of epigenetic regulation in the progression of silicosis

H Yin, Y Xie, P Gu, W Li, Y Zhang, Y Yao, W Chen… - Clinical …, 2022 - Springer
Silicosis is one of the most severe occupational diseases worldwide and is characterized by
silicon nodules and diffuse pulmonary fibrosis. However, specific treatments for silicosis are …

Virus hijacking of host epigenetic machinery to impair immune response

M Locatelli, S Faure-Dupuy - Journal of Virology, 2023 - Am Soc Microbiol
Epigenetic modifications, such as DNA hypermethylation, histone acetylation/methylation, or
nucleosome positioning, result in differential gene expression. These modifications can …

New molecular targets in Hodgkin and Reed-Sternberg cells

H Sadaf, M Ambroziak, R Binkowski… - Frontiers in …, 2023 - frontiersin.org
Recent discoveries shed light on molecular mechanisms responsible for classical Hodgkin
lymphoma (HL) development and progression, along with features of Hodgkin–Reed and …

Epigenetics in inflammatory breast cancer: biological features and therapeutic perspectives

FLC Faldoni, CA Rainho, SR Rogatto - Cells, 2020 - mdpi.com
Evidence has emerged implicating epigenetic alterations in inflammatory breast cancer
(IBC) origin and progression. IBC is a rare and rapidly progressing disease, considered the …

Novel methylation biomarkers for colorectal cancer prognosis

A Gutierrez, H Demond, P Brebi, CG Ili - Biomolecules, 2021 - mdpi.com
Colorectal cancer (CRC) comprises the third most common cancer worldwide and the
second regarding number of deaths. In order to make a correct and early diagnosis to …

Epigenomics and immunotherapeutic advances in pediatric brain tumors

M Abedalthagafi, N Mobark, M Al-Rashed… - NPJ Precision …, 2021 - nature.com
Brain tumors are the leading cause of childhood cancer-related deaths. Similar to adult brain
tumors, pediatric brain tumors are classified based on histopathological evaluations …

S100A11 activates the pentose phosphate pathway to induce malignant biological behaviour of pancreatic ductal adenocarcinoma

X Zeng, H Guo, Z Liu, Z Qin, Y Cong, N Ren… - Cell Death & …, 2022 - nature.com
Pancreatic ductal adenocarcinoma (PDAC) is one of the most refractory malignancies and
has a poor prognosis. In recent years, increasing evidence has shown that an imbalance of …

The multiple faces of NANOG in cancer: a therapeutic target to chemosensitize therapy-resistant cancers

H Fatma, HR Siddique, SK Maurya - Epigenomics, 2021 - Future Medicine
The transcription factor NANOG regulates self-renewal and pluripotency in embryonic cells,
and its downregulation leads to cell differentiation. Recent studies have linked upregulation …

Epigenetic regulation in Alzheimer's disease: is it a potential therapeutic target?

F Coppedè - Expert Opinion on Therapeutic Targets, 2021 - Taylor & Francis
Introduction: Alzheimer's disease (AD) is the most common neurodegenerative disorder and
the primary form of dementia in the elderly. Changes in DNA methylation and post …