Autoimmune myasthenia gravis: emerging clinical and biological heterogeneity

MN Meriggioli, DB Sanders - The Lancet Neurology, 2009 - thelancet.com
Acquired myasthenia gravis (MG) is an autoimmune disorder of the neuromuscular junction
in which patients experience fluctuating skeletal muscle weakness that often affects selected …

Myasthenia gravis: past, present, and future

BM Conti-Fine, M Milani… - The Journal of clinical …, 2006 - Am Soc Clin Investig
Myasthenia gravis (MG) is an autoimmune syndrome caused by the failure of neuromuscular
transmission, which results from the binding of autoantibodies to proteins involved in …

Impaired regulatory function in circulating CD4+ CD25highCD127low/− T cells in patients with myasthenia gravis

M Thiruppathi, J Rowin, B Ganesh, JR Sheng… - Clinical …, 2012 - Elsevier
Previous studies have reported alterations in numbers or function of regulatory T (Treg) cells
in myasthenia gravis (MG) patients, but published results have been inconsistent, likely due …

The nicotinic acetylcholine receptor: structure and autoimmune pathology

BM Conti-Tronconi, KE McLane… - Critical reviews in …, 1994 - Taylor & Francis
The nicotinic acetylcholine receptors (AChR) are presently the best-characterized
neurotransmitter receptors. They are pentamers of homologous or identical subunits …

Functional defect in regulatory T cells in myasthenia gravis

M Thiruppathi, J Rowin, Q Li Jiang… - Annals of the New …, 2012 - Wiley Online Library
Forkhead box P3 (FOXP3) is a transcription factor necessary for the function of regulatory T
cells (Treg cells). Treg cells maintain immune homeostasis and self‐tolerance and play an …

[HTML][HTML] Current treatment, emerging translational therapies, and new therapeutic targets for autoimmune myasthenia gravis

JT Guptill, M Soni, MN Meriggioli - Neurotherapeutics, 2016 - Elsevier
Myasthenia gravis (MG) is an autoimmune disease associated with the production of
autoantibodies against 1) the skeletal muscle acetylcholine receptor; 2) muscle-specific …

The thymus in myasthenia gravis: site of “innate autoimmunity”?

P Cavalcante, R Le Panse, S Berrih‐aknin… - Muscle & …, 2011 - Wiley Online Library
Myasthenia gravis (MG) is an autoimmune disorder caused, in most cases, by
autoantibodies against components of the neuromuscular junction, frequently the …

Characterization of CD4 and CD8 T cell responses in MuSK myasthenia gravis

JS Yi, A Guidon, S Sparks, R Osborne, VC Juel… - Journal of …, 2014 - Elsevier
Muscle specific tyrosine kinase myasthenia gravis (MuSK MG) is a form of autoimmune MG
that predominantly affects women and has unique clinical features, including prominent …

CD4+ T Cells and Cytokines in the Pathogenesis of Acquired Myasthenia Gravis

BM Conti‐Fine, M Milani… - Annals of the New York …, 2008 - Wiley Online Library
Although human and experimental acquired myasthenia gravis (MG) are prototypic antibody
(Ab)‐mediated autoimmune diseases, synthesis of the pathogenic anti‐acetylcholine …

Myasthenia gravis with anti-acetylcholine receptor antibodies

MN Meriggioli - Immune-Mediated Neuromuscular Diseases, 2009 - karger.com
Background/Aims: Autoimmune myasthenia gravis (MG) is a disorder of the neuromuscular
junction caused in the majority of patients by autoantibodies directed against the …