The goal of this review is to discuss how behavioral tests in mice relate to the pathological
and neuropsychological features seen in human Alzheimer's disease (AD), and present a …

Within the past decade, our understanding of the pathogenic mechanisms in Alzheimer's
disease (AD) has dramatically advanced because of the development of transgenic mouse …

In the present report, we extend previous findings in the 5XFAD mouse model and
demonstrate that these mice develop an age-dependent motor phenotype in addition to …

In Alzheimer's disease (AD), oxidative stress is present early and contributes to disease
pathogenesis. We previously reported that in Tg19959 transgenic AD mice, partial …

Increased oxidative stress is implicated in the pathogenesis of Alzheimer's disease (AD). A
large body of evidence suggests that mitochondrial dysfunction and increased reactive …

Alzheimer's disease (AD) is a progressive, age-dependent neurodegenerative disorder
affecting specific brain regions that control memory and cognitive functions. Epidemiological …

Introduction Despite the extensive mechanistic and pathological characterization of the
amyloid precursor protein (APP)/presenilin-1 (PS-1) knock-in mouse model of Alzheimer's …

Alzheimer's disease (AD) is a neurodegenerative disorder primarily affecting regions of the
brain responsible for higher cognitive functions. Immunization against β-amyloid (Aβ) in …

Numerous epidemiological studies link vascular disorders, such as hypertension, diabetes
mellitus, and stroke, with Alzheimer's disease (AD). Hypertension, specifically, is an …

The 5XFAD mice are an early‐onset transgenic model of Alzheimer's disease (AD) in which
amyloid plaques are first observed between two and four months of age in the cortical layer …