Molecular dialogs between the ischemic brain and the peripheral immune system: dualistic roles in injury and repair
Immune and inflammatory responses actively modulate the pathophysiological processes of
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …
acute brain injuries such as stroke. Soon after the onset of stroke, signals such as brain …
[HTML][HTML] Altered regulatory T cell homeostasis in patients with CD4+ lymphopenia following allogeneic hematopoietic stem cell transplantation
K Matsuoka, HT Kim, S McDonough… - The Journal of …, 2010 - Am Soc Clin Investig
CD4+ CD25+ Foxp3+ Tregs have an indispensable role in the maintenance of tolerance
after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease …
after allogeneic HSC transplantation (HSCT). Patients with chronic graft-versus-host disease …
Type 1 diabetes-associated IL2RA variation lowers IL-2 signaling and contributes to diminished CD4+ CD25+ regulatory T cell function
G Garg, JR Tyler, JHM Yang, AJ Cutler… - The Journal of …, 2012 - journals.aai.org
Numerous reports have demonstrated that CD4+ CD25+ regulatory T cells (Tregs) from
individuals with a range of human autoimmune diseases, including type 1 diabetes, are …
individuals with a range of human autoimmune diseases, including type 1 diabetes, are …
Trauma equals danger—damage control by the immune system
VM Stoecklein, A Osuka… - Journal of leukocyte …, 2012 - academic.oup.com
Review on how traumatic injuries influence immune system phenotypes and functions.
Traumatic injuries induce a complex host response that disrupts immune system …
Traumatic injuries induce a complex host response that disrupts immune system …
[HTML][HTML] Tumor-associated Tregs obstruct antitumor immunity by promoting T cell dysfunction and restricting clonal diversity in tumor-infiltrating CD8+ T cells
Background Accumulation of regulatory T cells (Treg) has been described to often correlate
with poor prognosis in many solid tumors. How Treg presence impinges on limited …
with poor prognosis in many solid tumors. How Treg presence impinges on limited …
[HTML][HTML] The characterization of regulatory T-cell profiles in Alzheimer's disease and multiple sclerosis
Abstract Regulatory T Cells (Tregs) are a T-lymphocyte subset involved in the maintenance
of immune peripheral tolerance. Despite evidence of the adaptive immune system's role in …
of immune peripheral tolerance. Despite evidence of the adaptive immune system's role in …
The alteration of Th1/Th2/Th17/Treg paradigm in patients with type 2 diabetes mellitus: relationship with diabetic nephropathy
C Zhang, C Xiao, P Wang, W Xu, A Zhang, Q Li, X Xu - Human immunology, 2014 - Elsevier
T cells have been demonstrated to exert central roles in the development of type 2 DN
(T2DN). To explore whether Th1/Th2/Th17/Treg paradigm plays an important role in the …
(T2DN). To explore whether Th1/Th2/Th17/Treg paradigm plays an important role in the …
Phase 1 clinical trial demonstrated that MUC1 positive metastatic seminal vesicle cancer can be effectively eradicated by modified Anti-MUC1 chimeric antigen …
F You, L Jiang, B Zhang, Q Lu, Q Zhou, X Liao… - Science China Life …, 2016 - Springer
Recent progress in chimeric antigen receptor-modified T-cell (CAR-T cell) technology in
cancer therapy is extremely promising, especially in the treatment of patients with B-cell …
cancer therapy is extremely promising, especially in the treatment of patients with B-cell …
In vivo depletion of CD4+FOXP3+ Treg cells by the PC61 anti‐CD25 monoclonal antibody is mediated by FcγRIII+ phagocytes
YY Setiady, JA Coccia, PU Park - European journal of …, 2010 - Wiley Online Library
Abstract Depletion of CD4+ CD25+ FoxP3+ Treg using PC61 mAb (anti‐murine CD25 rat
IgG1) is widely used to characterize Treg function in vivo. However, the mechanism of Treg …
IgG1) is widely used to characterize Treg function in vivo. However, the mechanism of Treg …
[HTML][HTML] Molecular mechanisms controlling Foxp3 expression in health and autoimmunity: from epigenetic to post-translational regulation
A Colamatteo, F Carbone, S Bruzzaniti… - Frontiers in …, 2020 - frontiersin.org
The discovery of the transcription factor Forkhead box-p3 (Foxp3) has shed fundamental
insights into the understanding of the molecular determinants leading to generation and …
insights into the understanding of the molecular determinants leading to generation and …