OX40 (CD134) and its binding partner, OX40L (CD252), are members of the tumor necrosis
factor receptor/tumor necrosis factor superfamily and are expressed on activated CD4+ and …

The current study identifies CCR8+ regulatory T cells (Treg cells) as drivers of
immunosuppression. We show that in human peripheral blood cells, more than 30% of Treg …

Rationale: Pulmonary arterial hypertension (PAH) is characterized by vasoconstriction and
vascular remodeling. Recent studies have revealed that immune and inflammatory …

Cellular therapies with polyclonal regulatory T-cells (Tregs) in transplantation and
autoimmune diseases have been carried out in both animal models and clinical trials …

Increasing incidences of obesity and diabetes have made diabetic kidney disease (DKD) the
leading cause of chronic kidney disease and end-stage renal disease worldwide. Despite …

Foxp3-expressing regulatory T (T reg) cells have been implicated in parasite-driven
inhibition of host immunity during chronic infection. We addressed whether parasites can …

Clinical, epidemiological, and molecular studies have sufficiently highlighted the vitality of
vitamin D [25 (OH) D and 1, 25 (OH) 2D] in human health and wellbeing. Globally, vitamin D …

Immune tolerance to tumors is often associated with accumulation of myeloid-derived
suppressor cells (MDSC) and an increase in the number of T-regulatory cells (Treg). In …

Transcription factor Foxp3 (forkhead box P3), restricted in its expression to a specialized
regulatory CD4+ T-cell subset (TR) with a dedicated suppressor function, controls TR …

The dynamics of CD4+ effector T cells (Teff cells) and CD4+ Foxp3+ regulatory T cells (Treg
cells) during diabetes progression in nonobese diabetic mice was investigated to determine …