Summary CD4+ Foxp3+ regulatory T (Treg) cells originate primarily from thymic
differentiation, but conversion of mature T lymphocytes to Foxp3 positivity can be elicited by …

The new WHO Roadmap for Neglected Tropical Diseases targets the global elimination of
schistosomiasis as a public health problem. To date, control strategies have focused on …

Multiple sclerosis is one of the most common causes of chronic neurological disability
beginning in early to middle adult life. Multiple sclerosis is idiopathic in nature, yet …

T cell reconstitution following lymphopenia from chemotherapy or stem cell transplant is
often slow and incompetent, contributing to the development of infectious diseases, relapse …

CCR8 is a chemokine receptor expressed principally on regulatory T cells (Treg) and is
known to be critical for CCR8+ Treg-mediated immunosuppression. Recent studies have …

Foxp3+ regulatory T cells (Tregs) contribute significantly to the maintenance of peripheral
tolerance, but they ultimately fail in autoimmune diseases. The events that lead to Treg …

The PTPN22 locus is one of the strongest risk factors outside of the major histocompatability
complex that associates with autoimmune diseases. PTPN22 encodes lymphoid protein …

Abstract Human CD4+ CD25highCD127− FoxP3+ regulatory T (Treg) cells suppress
immune responses in vitro and in vivo. Reduced suppressive function and/or number of …

Despite the skepticism that once prevailed among immunologists, it is now widely accepted
that the normal immune system harbors a T-cell population, called regulatory T cells (Treg …

T-cells play a key role within the adaptive immune system mediating cellular immunity and
orchestrating the immune response as a whole. Their activation requires not only …