Topography-mediated immunomodulation in osseointegration; Ally or Enemy

S Shirazi, S Ravindran, LF Cooper - Biomaterials, 2022 - Elsevier
Osteoimmunology is at full display during endosseous implant osseointegration. Bone
formation, maintenance and resorption at the implant surface is a result of bidirectional and …

Osteoblast differentiation and signaling: established concepts and emerging topics

M Ponzetti, N Rucci - International Journal of Molecular Sciences, 2021 - mdpi.com
Osteoblasts, the cells that build up our skeleton, are remarkably versatile and important cells
that need tight regulation in all the phases of their differentiation to guarantee proper skeletal …

Exosomes derived from reparative M2-like macrophages prevent bone loss in murine periodontitis models via IL-10 mRNA

X Chen, Z Wan, L Yang, S Song, Z Fu, K Tang… - Journal of …, 2022 - Springer
Background Periodontitis is characterized by progressive inflammation and alveolar bone
loss resulting in tooth loss finally. Macrophages including pro-inflammatory M1-like …

Exosomal miRNA-mediated intercellular communications and immunomodulatory effects in tumor microenvironments

HM Nail, CC Chiu, CH Leung, MMM Ahmed… - Journal of biomedical …, 2023 - Springer
Extracellular communication, in other words, crosstalk between cells, has a pivotal role in
the survival of an organism. This communication occurs by different methods, one of which is …

A review of 3D polymeric scaffolds for bone tissue engineering: principles, fabrication techniques, immunomodulatory roles, and challenges

AG Abdelaziz, H Nageh, SM Abdo, MS Abdalla… - Bioengineering, 2023 - mdpi.com
Over the last few years, biopolymers have attracted great interest in tissue engineering and
regenerative medicine due to the great diversity of their chemical, mechanical, and physical …

Remotely temporal scheduled macrophage phenotypic transition enables optimized immunomodulatory bone regeneration

D Huang, K Xu, X Huang, N Lin, Y Ye, S Lin, J Zhang… - Small, 2022 - Wiley Online Library
Precise timing of macrophage polarization plays a pivotal role in immunomodulation of
tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti …

Mesenchymal stem cell-macrophage crosstalk and maintenance of inflammatory microenvironment homeostasis

D Lu, Y Xu, Q Liu, Q Zhang - Frontiers in cell and developmental …, 2021 - frontiersin.org
Macrophages are involved in almost every aspect of biological systems and include
development, homeostasis and repair. Mesenchymal stem cells (MSCs) have good clinical …

Immunoporosis: Role of immune system in the pathophysiology of different types of osteoporosis

W Zhang, R Gao, X Rong, S Zhu, Y Cui… - Frontiers in …, 2022 - frontiersin.org
Osteoporosis is a skeletal system disease characterized by low bone mass and altered bone
microarchitecture, with an increased risk of fractures. Classical theories hold that …

Application of bone marrow-derived macrophages combined with bone mesenchymal stem cells in dual-channel three-dimensional bioprinting scaffolds for early …

K Yu, H Huangfu, Q Qin, Y Zhang, X Gu… - … Applied Materials & …, 2022 - ACS Publications
The host immune response to biomaterials is critical for determining scaffold fate and bone
regeneration outcomes. Three-dimensional (3D) bioprinted scaffolds encapsulated with …

[HTML][HTML] Mesenchymal stem cells and macrophages and their interactions in tendon-bone healing

Z Chen, M Jin, H He, J Dong, J Li, J Nie, Z Wang… - Journal of Orthopaedic …, 2023 - Elsevier
Tendon-bone insertion injuries (TBI), such as anterior cruciate ligament (ACL) and rotator
cuff injuries, are common degenerative or traumatic pathologies with a negative impact on …