Immuno-oncology has revolutionized cancer treatment and has opened up new
opportunities for developing vaccination methods. DNA-based cancer vaccines have …

Human papillomavirus (HPV) infection represents a significant global health concern owing
to its role in the etiology of conditions ranging from benign low-grade lesions to cancers of …

Vaccination is one of the most successful measures in modern medicine to combat
diseases, especially infectious diseases, and saves millions of lives every year. Vaccine …

Tumor vaccines aim to activate dormant or unresponsive tumor-specific T lymphocytes by
using tumor-specific or tumor-associated antigens, thus enhancing the body's natural …

Over the past decades, significant progress has been made in utilizing nucleic acids,
including DNA and RNA molecules, for therapeutic purposes. For DNA molecules, although …

The concept of DNA vaccination was introduced in the early 1990s. Since then,
advancements in the augmentation of the immunogenicity of DNA vaccines have brought …

After two years since the declaration of COVID-19 as a pandemic by the World Health
Organization (WHO), more than six million deaths have occurred due to SARS-CoV-2 …

In recent years, lipid nanoparticles (LNPs) have emerged as a revolutionary technology for
vaccine delivery. LNPs serve as an integral component of mRNA vaccines by protecting and …

Immunotherapy efficacy as monotherapy is negligible for glioblastoma (GBM). We
hypothesized that combining therapeutic vaccination using a plasmid encoding an epitope …

Neoantigen-based cancer vaccines have emerged as a promising immunotherapeutic
approach to treat cancer. Nevertheless, the high degree of heterogeneity in tumors poses a …