Role of mesenchymal stem/stromal cells in modulating ischemia/reperfusion injury: current state of the art and future perspectives

V Miceli, M Bulati, A Gallo, G Iannolo, R Busà… - Biomedicines, 2023 - mdpi.com
Ischemia/reperfusion injury (IRI) is a multistep damage that occurs in several tissues when a
blood flow interruption is inevitable, such as during organ surgery or transplantation. It is …

Novel approaches for long-term lung transplant survival

CL Miller, JM O, JS Allan, JC Madsen - Frontiers in Immunology, 2022 - frontiersin.org
Allograft failure remains a major barrier in the field of lung transplantation and results
primarily from acute and chronic rejection. To date, standard-of-care immunosuppressive …

Normothermic Ex Vivo Heart Perfusion with Mesenchymal Stem Cell‐Derived Conditioned Medium Improves Myocardial Tissue Protection in Rat Donation after …

Z Zeng, L Xu, Y Xu, Y Ruan, D Liu, J Li… - Stem Cells …, 2022 - Wiley Online Library
Objective. Adopting hearts from donation after circulatory death (DCD) is a promising
approach to enlarge the donor pool. Nevertheless, DCD hearts experience severe warm …

[HTML][HTML] Utilizing pathophysiological concepts of ischemia-reperfusion injury to design renoprotective strategies and therapeutic interventions for normothermic ex vivo …

B Ogurlu, TL Hamelink, IM Van Tricht… - American Journal of …, 2024 - Elsevier
Normothermic machine perfusion (NMP) has emerged as a promising tool for the
preservation, viability assessment, and repair of deceased-donor kidneys prior to …

Clinical implications of differential functional capacity between tissue‐specific human mesenchymal stromal/stem cells

BL Yen, KJ Liu, HK Sytwu, ML Yen - The FEBS Journal, 2023 - Wiley Online Library
Over the past two decades, there has been an explosion in the numbers of clinical trials
using mesenchymal stem cells (MSCs). While the safety profile of MSC therapy has been …

Mesenchymal Stem Cells and Extracellular Vesicles: Therapeutic Potential in Organ Transplantation

W Pan, S Li, K Li, P Zhou - Stem Cells International, 2024 - Wiley Online Library
At present, organ transplantation remains the most appropriate therapy for patients with end‐
stage organ failure. However, the field of organ transplantation is still facing many …

Structural and temporal dynamics of mesenchymal stem cells in liver diseases from 2001 to 2021: a bibliometric analysis

B Shao, Y Qin, S Ren, Q Peng, H Qin, Z Wang… - Frontiers in …, 2022 - frontiersin.org
Background Mesenchymal stem cells (MSCs) have important research value and broad
application prospects in liver diseases. This study aims to comprehensively review the …

供肝保存与功能维护助力肝移植发展.

谢炎, 蒋文涛 - Organ Transplantation/Qi Guan Yi Zhi, 2023 - search.ebscohost.com
肝移植作为终末期肝病的有效治疗方法已在世界范围内广泛开展, 并逐渐取得普遍认可.
随着肝移植手术技术趋于成熟, 术后并发症发生率逐步降低, 受者的短期和长期预后持续改善 …

An Analysis of 10,000 Cases of Living Donor Liver Transplantation in Japan: Special Reference to the Graft-Versus-Recipient Weight Ratio and Donor Age

S Eguchi, K Umeshita, Y Soejima, H Eguchi… - Annals of …, 2024 - journals.lww.com
Objective: To analyze 10,000 cases of living donor liver transplantation (LDLT) recipient
data to elucidate outcomes with special reference to the graft-versus-recipient weight ratio …

间充质干细胞及其衍生物对供肝修复的潜在价值.

王依婷, 江杰, 马丽, 胡宗强… - Organ Transplantation/Qi …, 2023 - search.ebscohost.com
近年来, 我国器官移植工作发展迅速, 器官供需比例严重失衡. 为解决供肝短缺问题,
修复扩大标准供肝, 改善供肝质量是当前的重要研究方向. 间充质干细胞是一类具有自我更新 …