[HTML][HTML] The genetic basis of major depressive disorder

J Flint - Molecular psychiatry, 2023 - nature.com
The genetic dissection of major depressive disorder (MDD) ranks as one of the success
stories of psychiatric genetics, with genome-wide association studies (GWAS) identifying …

Obesity: global epidemiology and pathogenesis

M Blüher - Nature Reviews Endocrinology, 2019 - nature.com
The prevalence of obesity has increased worldwide in the past~ 50 years, reaching
pandemic levels. Obesity represents a major health challenge because it substantially …

Heart disease and stroke statistics—2019 update: a report from the American Heart Association

EJ Benjamin, P Muntner, A Alonso, MS Bittencourt… - Circulation, 2019 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the National
Institutes of Health and other government agencies, brings together in a single document the …

RNA demethylation increases the yield and biomass of rice and potato plants in field trials

Q Yu, S Liu, L Yu, Y Xiao, S Zhang, X Wang, Y Xu… - Nature …, 2021 - nature.com
Abstract RNA N 6-methyladenosine (m6A) modifications are essential in plants. Here, we
show that transgenic expression of the human RNA demethylase FTO in rice caused a more …

FTO in cancer: functions, molecular mechanisms, and therapeutic implications

Y Li, R Su, X Deng, Y Chen, J Chen - Trends in cancer, 2022 - cell.com
N 6-methyladenosine (m 6 A) is the most abundant internal modification in mRNA that
affects RNA processing, stability, and translation. Discovered as the first RNA m 6 A …

[HTML][HTML] Dynamic transcriptomic m6A decoration: writers, erasers, readers and functions in RNA metabolism

Y Yang, PJ Hsu, YS Chen, YG Yang - Cell research, 2018 - nature.com
Abstract N 6-methyladenosine (m6A) is a chemical modification present in multiple RNA
species, being most abundant in mRNAs. Studies on enzymes or factors that catalyze …

Heart disease and stroke statistics—2018 update: a report from the American Heart Association

EJ Benjamin, SS Virani, CW Callaway… - Circulation, 2018 - Am Heart Assoc
Summary Each year, the American Heart Association (AHA), in conjunction with the Centers
for Disease Control and Prevention, the National Institutes of Health, and other government …

[HTML][HTML] Obesity and bone: a complex relationship

G Rinonapoli, V Pace, C Ruggiero, P Ceccarini… - International journal of …, 2021 - mdpi.com
There is a large literature on the relationship between obesity and bone. What we can
conclude from this review is that the increase in body weight causes an increase in BMD …

Meta-analysis of genome-wide association studies for body fat distribution in 694 649 individuals of European ancestry

SL Pulit, C Stoneman, AP Morris… - Human molecular …, 2019 - academic.oup.com
More than one in three adults worldwide is either overweight or obese. Epidemiological
studies indicate that the location and distribution of excess fat, rather than general adiposity …

[HTML][HTML] RNA N6-methyladenosine demethylase FTO promotes breast tumor progression through inhibiting BNIP3

Y Niu, Z Lin, A Wan, H Chen, H Liang, L Sun, Y Wang… - Molecular cancer, 2019 - Springer
Abstract Background N6-methyladenosine (m6A) modification is the most pervasive
modification in mRNA, and has been considered as a new layer of epigenetic regulation on …