N6-methyladenosine demethylase FTO targets pre-mRNAs and regulates alternative splicing and 3′-end processing
M Bartosovic, HC Molares, P Gregorova… - Nucleic acids …, 2017 - academic.oup.com
Abstract N6-methyladenosine (m6A) is the most abundant base modification found in
messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase …
messenger RNAs (mRNAs). The discovery of FTO as the first m6A mRNA demethylase …
[HTML][HTML] Risk factors contributing to type 2 diabetes and recent advances in the treatment and prevention
Y Wu, Y Ding, Y Tanaka, W Zhang - International journal of medical …, 2014 - ncbi.nlm.nih.gov
Type 2 diabetes is a serious and common chronic disease resulting from a complex
inheritance-environment interaction along with other risk factors such as obesity and …
inheritance-environment interaction along with other risk factors such as obesity and …
Brain insulin resistance at the crossroads of metabolic and cognitive disorders in humans
Ever since the brain was identified as an insulin-sensitive organ, evidence has rapidly
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
accumulated that insulin action in the brain produces multiple behavioral and metabolic …
[HTML][HTML] Ghrelin
Background The gastrointestinal peptide hormone ghrelin was discovered in 1999 as the
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
endogenous ligand of the growth hormone secretagogue receptor. Increasing evidence …
Heart disease and stroke statistics—2020 update: a report from the American Heart Association
Background: The American Heart Association, in conjunction with the National Institutes of
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …
Health, annually reports on the most up-to-date statistics related to heart disease, stroke …
[HTML][HTML] Heart disease and stroke statistics-2021 update: a report from the American Heart Association.
Background The American Heart Association, in conjunction with the National Institutes of
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
Health, annually reports the most up-to-date statistics related to heart disease, stroke, and …
The role of regulatory variation in complex traits and disease
FW Albert, L Kruglyak - Nature Reviews Genetics, 2015 - nature.com
We are in a phase of unprecedented progress in identifying genetic loci that cause variation
in traits ranging from growth and fitness in simple organisms to disease in humans …
in traits ranging from growth and fitness in simple organisms to disease in humans …
FTO-dependent demethylation of N6-methyladenosine regulates mRNA splicing and is required for adipogenesis
Abstract The role of Fat Mass and Obesity-associated protein (FTO) and its substrate N6-
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …
methyladenosine (m 6 A) in mRNA processing and adipogenesis remains largely unknown …
N6-methyladenosine-dependent regulation of messenger RNA stability
Abstract N 6-methyladenosine (m6A) is the most prevalent internal (non-cap) modification
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …
present in the messenger RNA of all higher eukaryotes,. Although essential to cell viability …
Precision nutrition: a review of personalized nutritional approaches for the prevention and management of metabolic syndrome
The translation of the growing increase of findings emerging from basic nutritional science
into meaningful and clinically relevant dietary advices represents nowadays one of the main …
into meaningful and clinically relevant dietary advices represents nowadays one of the main …