The contribution of genetics and environment to obesity
Background Obesity is a global health problem mainly attributed to lifestyle changes such as
diet, low physical activity or socioeconomics factors. However, several evidences …
diet, low physical activity or socioeconomics factors. However, several evidences …
Dynamics of the human and viral m6A RNA methylomes during HIV-1 infection of T cells
Abstract N 6-methyladenosine (m 6 A) is the most prevalent internal modification of
eukaryotic mRNA. Very little is known of the function of m 6 A in the immune system or its …
eukaryotic mRNA. Very little is known of the function of m 6 A in the immune system or its …
Insulin resistance and the polycystic ovary syndrome revisited: an update on mechanisms and implications
E Diamanti-Kandarakis, A Dunaif - Endocrine reviews, 2012 - academic.oup.com
Polycystic ovary syndrome (PCOS) is now recognized as an important metabolic as well as
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …
reproductive disorder conferring substantially increased risk for type 2 diabetes. Affected …
Meclofenamic acid selectively inhibits FTO demethylation of m6A over ALKBH5
Y Huang, J Yan, Q Li, J Li, S Gong, H Zhou… - Nucleic acids …, 2015 - academic.oup.com
Two human demethylases, the fat mass and obesity-associated (FTO) enzyme and ALKBH5,
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
oxidatively demethylate abundant N 6-methyladenosine (m6A) residues in mRNA …
Autophagy—a key player in cellular and body metabolism
KH Kim, MS Lee - Nature Reviews Endocrinology, 2014 - nature.com
Abstract Knowledge gained over the past 10 years about the mechanisms that underpin
autophagy has provided a universal framework for studies of diverse physiological and …
autophagy has provided a universal framework for studies of diverse physiological and …
Cohort profile: the 'children of the 90s'—the index offspring of the Avon Longitudinal Study of Parents and Children
A Boyd, J Golding, J Macleod, DA Lawlor… - International journal …, 2013 - academic.oup.com
Abstract The Avon Longitudinal Study of Parents and Children (ALSPAC) is a
transgenerational prospective observational study investigating influences on health and …
transgenerational prospective observational study investigating influences on health and …
A high-coverage genome sequence from an archaic Denisovan individual
We present a DNA library preparation method that has allowed us to reconstruct a high-
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
coverage (30×) genome sequence of a Denisovan, an extinct relative of Neandertals. The …
Cohort profile: the Avon Longitudinal Study of Parents and Children: ALSPAC mothers cohort
Abstract Summary The Avon Longitudinal Study of Children and Parents (ALSPAC) was
established to understand how genetic and environmental characteristics influence health …
established to understand how genetic and environmental characteristics influence health …
The genetics of major depression
J Flint, KS Kendler - Neuron, 2014 - cell.com
Major depression is the commonest psychiatric disorder and in the US has the greatest
impact of all biomedical diseases on disability. Here we review evidence of the genetic …
impact of all biomedical diseases on disability. Here we review evidence of the genetic …
N6-Methyladenosine in nuclear RNA is a major substrate of the obesity-associated FTO
We report here that fat mass and obesity-associated protein (FTO) has efficient oxidative
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …
demethylation activity targeting the abundant N 6-methyladenosine (m6A) residues in RNA …