THE production of hormones and other protein markers by tumors has been an intriguing
area of tumor biology. It has become apparent during the last decades that a wide range of …

I. Introduction W ITH the advent of synthetic glucocorticoids in the late 1940s, adrenalectomy
ushered in the modern era of treatment for Cushing's syndrome. Nearly two decades later …

Objective: The objective is to formulate clinical practice guidelines for treating Cushing's
syndrome. Participants: Participants include an Endocrine Society-appointed Task Force of …

Context Although transsphenoidal surgery remains the first-line treatment in Cushing's
disease (CD), recurrence is observed in about 20% of cases. Adjunctive treatments each …

Paraneoplastic phenomena associated with primary lung cancer have diverse initial
manifestations and epitomize the systemic nature of human malignant disease. The …

Several substances with different inhibitory effects on adrenal steroid biosynthesis were
investigated in patients with Cushing's syndrome. It has been shown that trilostane, a 3β …

The multiple effects of estrogens on infectious processes are only beginning to be
understood. The existence of such effects is suggested by gender-related differences in the …

PURPOSE To evaluate the safety and efficacy of ketoconazole treatment in the management
of patients with paraneoplastic Cushing's syndrome (CS) secondary to ectopic …

The antifungal agent ketoconazole is often used to suppress cortisol production in patients
with Cushing's syndrome (CS). However, ketoconazole has serious side effects and is …

Ketoconazole, an imidazole derivative which Inhibits adrenal steroidogenesis, has been
used with success for the metabolic control of Cushing's disease. Few data are available …