[HTML][HTML] CAR-cell therapy in the era of solid tumor treatment: current challenges and emerging therapeutic advances
In the last decade, Chimeric Antigen Receptor (CAR)-T cell therapy has emerged as a
promising immunotherapeutic approach to fight cancers. This approach consists of …
promising immunotherapeutic approach to fight cancers. This approach consists of …
[HTML][HTML] Aberrant sialylation in cancer: biomarker and potential target for therapeutic intervention?
S Pietrobono, B Stecca - Cancers, 2021 - mdpi.com
Simple Summary Sialylation is a post-translational modification that consists in the addition
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …
of sialic acid to growing glycan chains on glycoproteins and glycolipids. Aberrant sialylation …
[HTML][HTML] Sialic acids in pancreatic cancer cells drive tumour-associated macrophage differentiation via the Siglec receptors Siglec-7 and Siglec-9
E Rodriguez, K Boelaars, K Brown… - Nature …, 2021 - nature.com
Abstract Changes in glycosylation during tumour progression are a key hallmark of cancer.
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …
One of the glycan moieties generally overexpressed in cancer are sialic acids, which can …
Siglec and anti-Siglec therapies
G Murugesan, B Weigle, PR Crocker - Current opinion in chemical biology, 2021 - Elsevier
Siglecs (sialic acid–binding immunoglobulin-like lectins) are a family of receptors that bind
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …
sialic acids in specific linkages on glycoproteins and glycolipids. Siglecs play roles in …
[HTML][HTML] Inhibitory receptors and checkpoints in human NK cells, implications for the immunotherapy of cancer
The highly destructive mechanisms by which the immune system faces microbial infections
is under the control of a series of inhibitory receptors. While most of these receptors prevent …
is under the control of a series of inhibitory receptors. While most of these receptors prevent …
Siglec-7 glyco-immune binding mAbs or NK cell engager biologics induce potent antitumor immunity against ovarian cancers
D Bordoloi, AJ Kulkarni, OS Adeniji, MB Pampena… - Science …, 2023 - science.org
Ovarian cancer (OC) is a lethal gynecologic malignancy, with modest responses to CPI.
Engagement of additional immune arms, such as NK cells, may be of value. We focused on …
Engagement of additional immune arms, such as NK cells, may be of value. We focused on …
[HTML][HTML] The intriguing roles of Siglec family members in the tumor microenvironment
KY Jiang, LL Qi, FB Kang, L Wang - Biomarker Research, 2022 - Springer
Sialic acid-binding receptors are expressed on the surfaces of a variety of immune cells and
have complex and diverse immunoregulatory functions in health and diseases. Recent …
have complex and diverse immunoregulatory functions in health and diseases. Recent …
[HTML][HTML] Siglecs as therapeutic targets in cancer
Simple Summary Hyperglycosylated cancer cells are often decorated with abundant sialic
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …
acids, which are recognized by Sialic acid binding immunoglobulin type lectins (Siglecs) …
[HTML][HTML] Current status on therapeutic molecules targeting Siglec receptors
MP Lenza, U Atxabal, I Oyenarte, J Jiménez-Barbero… - Cells, 2020 - mdpi.com
The sialic acid-binding immunoglobulin-type of lectins (Siglecs) are receptors that recognize
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …
sialic acid-containing glycans. In the majority of the cases, Siglecs are expressed on …
[HTML][HTML] The role of glycosylation in melanoma progression
C De Vellis, S Pietrobono, B Stecca - Cells, 2021 - mdpi.com
Malignant melanoma is the most aggressive form of skin cancer, which originates from the
malignant transformation of melanocytes, the melanin-producing cells of the skin. Melanoma …
malignant transformation of melanocytes, the melanin-producing cells of the skin. Melanoma …