Background Cancers with a defective DNA mismatch repair (dMMR) system contain
thousands of mutations most frequently located in monomorphic microsatellites and are …

Simple Summary The abundance and the dynamic of the studies on NSCLC require
frequent summaries of the current achievements in the field. In our review, we aimed to …

Genomic instability is a characteristic of most cancer cells. It is an increased tendency of
genome alteration during cell division. Cancer frequently results from damage to multiple …

DNA mismatches represent a novel target in the development of diagnostics and
therapeutics for cancer, because deficiencies in DNA mismatch repair are implicated in …

Prediction of prognosis in colorectal cancer is vital for the choice of therapeutic options.
Histopathological factors remain paramount in this respect. Factors such as tumor size …

The microsatellite instability (MSI) pathway is one of the important mutational pathways that
play a critical role in colorectal carcinogenesis. About 15% of colorectal cancers (CRCs) are …

Ovarian cancer ranks fifth in both cancer incidence and mortality among women in the
United States. Defects in the mismatch‐repair (MMR) pathway that arise through genetic …

Microsatellite instability (MSI)/defective DNA mismatch repair (dMMR) is receiving more
attention as a biomarker for eligibility for immune checkpoint inhibitors in advanced …

The AT-rich interactive domain 1A gene (ARID1A), which encodes one of the subunits in the
Switch/Sucrose Nonfermentable chromatin remodeling complex, carries mutations and is …

AIMS: The prediction of sensitivity and resistance to neoadjuvant therapy has great potential
value for many tumour sites. A neoadjuvant regimen is increasingly the gold standard in …