[HTML][HTML] Tumor-induced perturbations of cytokines and immune cell networks
Until recently, the intrinsically high level of cross-talk between immune cells, the complexity
of immune cell development, and the pleiotropic nature of cytokine signaling have …
of immune cell development, and the pleiotropic nature of cytokine signaling have …
[HTML][HTML] TGFβ in cancer
J Massagué - Cell, 2008 - cell.com
The transforming growth factor β (TGFβ) signaling pathway is a key player in metazoan
biology, and its misregulation can result in tumor development. The regulatory cytokine …
biology, and its misregulation can result in tumor development. The regulatory cytokine …
TGF-beta in CAF-mediated tumor growth and metastasis
TGF-beta signaling is one of the major pathways controlling cell and tissue behavior not only
in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes …
in homeostasis but also in disease. During tumorigenesis TGF-beta orchestrated processes …
Transforming growth factor β superfamily signaling in development of colorectal cancer
B Jung, JJ Staudacher, D Beauchamp - Gastroenterology, 2017 - Elsevier
Transforming growth factor (TGF)-β cytokines signal via a complex network of pathways to
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …
regulate proliferation, differentiation, adhesion, migration, and other functions in many cell …
Transforming growth factor β as regulator of cancer stemness and metastasis
C Bellomo, L Caja, A Moustakas - British journal of cancer, 2016 - nature.com
Key elements of cancer progression towards metastasis are the biological actions of cancer
stem cells and stromal cells in the tumour microenvironment. Cross-communication between …
stem cells and stromal cells in the tumour microenvironment. Cross-communication between …
Microenvironmental regulation of stem cells in intestinal homeostasis and cancer
JP Medema, L Vermeulen - Nature, 2011 - nature.com
The identification of intestinal stem cells as well as their malignant counterparts, colon
cancer stem cells, has undergone rapid development in recent years. Under physiological …
cancer stem cells, has undergone rapid development in recent years. Under physiological …
How tolerogenic dendritic cells induce regulatory T cells
RA Maldonado, UH von Andrian - Advances in immunology, 2010 - Elsevier
Since their discovery by Steinman and Cohn in 1973, dendritic cells (DCs) have become
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …
increasingly recognized for their crucial role as regulators of innate and adaptive immunity …
Molecular networks that regulate cancer metastasis
D Spano, C Heck, P De Antonellis, G Christofori… - Seminars in cancer …, 2012 - Elsevier
Tumor metastases are responsible for approximately 90% of all cancer-related deaths.
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …
Although many patients can be cured, in the US and UK, cancer still causes 730,000 deaths …
[HTML][HTML] Role of transforming growth factor-β superfamily signaling pathways in human disease
KJ Gordon, GC Blobe - Biochimica et Biophysica Acta (BBA)-Molecular …, 2008 - Elsevier
Transforming growth factor β (TGF-β) superfamily signaling pathways are ubiquitous and
essential regulators of cellular processes including proliferation, differentiation, migration …
essential regulators of cellular processes including proliferation, differentiation, migration …
The tumour microenvironment as a target for chemoprevention
A Albini, MB Sporn - Nature Reviews Cancer, 2007 - nature.com
New data indicate that primary dysfunction in the tumour microenvironment, in addition to
epithelial dysfunction, can be crucial for carcinogenesis. These recent findings make a …
epithelial dysfunction, can be crucial for carcinogenesis. These recent findings make a …