Glutathione transferase classical GSH conjugation activity plays a critical role in cellular
detoxification against xenobiotics and noxious compounds as well as against oxidative …

The effectiveness of many anticancer drugs depends on the creation of specific metabolites
that may alter their therapeutic or toxic properties. One significant route of biotransformation …

We have previously demonstrated that selenium nanoparticles (SeNPs) administered via
oral route possess similar capacities of increasing selenoenzyme activities as the …

ABSTRACT Introduction: Busulfan (Bu) is an alkylating agent with a limited therapeutic
margin and exhibits inter-patient variability in pharmacokinetics (PK). Despite decades of …

In cases of cellular injury, there is an observed increase in the production of reactive oxygen
species (ROS). When this production becomes excessive, it can result in various conditions …

We aimed to review the pharmacokinetics (PK) of intravenous busulfan in paediatric
patients, identify covariate factors influencing exposure, investigate evidence of changes in …

Many potentially toxic electrophilic xenobiotics and some endogenous compounds are
detoxified by conversion to the corresponding glutathione S-conjugate, which is metabolized …

DNA alkylating drugs have been used as cancer chemotherapy with variable outcomes. The
establishment of predictive biomarkers to identify patients who will effectively respond to …

Selenium participates in the antioxidant defense mainly through a class of selenoproteins,
including thioredoxin reductase. Epigallocatechin-3-gallate (EGCG) is the most abundant …

This study aimed to characterize the population pharmacokinetics (PK) of busulfan focusing
on how busulfan clearance (CL) changes over time during once‐daily administration and …