Calcium signalling plays a crucial role in the control of neuronal function and plasticity.
Changes in neuronal Ca 2+ concentration are detected by Ca 2+-binding proteins that can …

Objective. Connectome disruption is a hallmark of many neurological diseases and trauma
with no current strategies to restore lost long-distance axonal pathways in the brain. We are …

Abstract Calcium (Ca 2+) is an important intracellular messenger underlying cell physiology.
Ca 2+ channels are the main entry route for Ca 2+ into excitable cells, and regulate …

As a common feature of many neurological diseases and injury, the loss of axon pathways
can have devastating effects on function. Here, we demonstrate a new strategy to restore …

Axonal regeneration is inhibited by a plethora of different mechanisms in the adult central
nervous system (CNS). While neurotrophic factors have been shown to stimulate axonal …

The corticospinal tract (CST) is extensively used as a model system for assessing potential
therapies to enhance neuronal regeneration and functional recovery following spinal cord …

Microglia are activated after spinal cord injury (SCI), but their phagocytic mechanisms and
link to neuroprotection remain incompletely characterized. Docosahexaenoic acid (DHA) …

Abstract Changes in the intracellular free calcium concentration ([Ca 2+] i) in neurons
regulate many and varied aspects of neuronal function over time scales from microseconds …

The incidence of neurodegenerative diseases is increasing due to changing age
demographics and the incidence of sports-related traumatic brain injury is tending to …

Spinal cord injury (SCI) affects millions of people worldwide and causes a significant
physical, emotional, social and economic burden. The main clinical hallmark of SCI is the …